Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A MAP OF THE HUMAN-IMMUNOGLOBULIN V-H LOCUS COMPLETED BY ANALYSIS OF THE TELOMERIC REGION OF CHROMOSOME 14Q
Autore:
COOK GP; TOMLINSON IM; WALTER G; RIETHMAN H; CARTER NP; BULUWELA L; WINTER G; RABBITTS TH;
Indirizzi:
MRC,MOLEC BIOL LAB,HILLS RD CAMBRIDGE CB2 2QH ENGLAND MRC,MOLEC BIOL LAB CAMBRIDGE CB2 2QH ENGLAND MRC,CTR PROT ENGN CAMBRIDGE CB2 2QH CAMBS ENGLAND WISTAR INST ANAT & BIOL PHILADELPHIA PA 19104 UNIV CAMBRIDGE,DEPT PATHOL CAMBRIDGE CB2 1QP ENGLAND
Titolo Testata:
Nature genetics
fascicolo: 2, volume: 7, anno: 1994,
pagine: 162 - 168
SICI:
1061-4036(1994)7:2<162:AMOTHV>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAVY-CHAIN LOCUS; VARIABLE REGION; ANTIBODY REPERTOIRE; V(H) SEGMENTS; PHYSICAL MAP; 5' EXON; GENE; ORGANIZATION; YEAST; CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
G.P. Cook et al., "A MAP OF THE HUMAN-IMMUNOGLOBULIN V-H LOCUS COMPLETED BY ANALYSIS OF THE TELOMERIC REGION OF CHROMOSOME 14Q", Nature genetics, 7(2), 1994, pp. 162-168

Abstract

Analysis of the telomeric region of chromosome 14q has enabled us to complete a map of the immunoglobulin V-H locus which accounts for almost all V-H segments known to rearrange in B-lymphocytes. The human germline V-H repertoire consists of approximately 50 functional V-H segments - the exact number depending on the haplotype - spanning 1,100 kilobases upstream of the J(H) segments. A yeast artificial chromosome used to map these segments was isolated by its ability to provide telomere activity in yeast, suggesting that the V-H locus may be located within a few kilobases of the 14q telomere. The limited structural diversity encoded by the functional V-H segments demonstrates the importanceof combinatorial diversity produced by VDJ joining and the association of heavy and light chains in producing the human antibody repertoire.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 09:28:02