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Titolo:
RED-BLOOD-CELL AGGREGATION AND MICROCIRCULATION IN RAT CREMASTER MUSCLE
Autore:
VICAUT E; HOU X; DECUYPERE L; TACCOEN A; DUVELLEROY M;
Indirizzi:
HOP FERNAND WIDAL,DEPT BIOPHYS,ETUD MICROCIRCULAT LAB,200 RUE FG ST DENIS F-75010 PARIS FRANCE HOP FERNAND WIDAL,INSERM,U141 PARIS FRANCE
Titolo Testata:
International journal of microcirculation, clinical and experimental
fascicolo: 1-2, volume: 14, anno: 1994,
pagine: 14 - 21
SICI:
0167-6865(1994)14:1-2<14:RAAMIR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA SUBSTITUTES; VENOUS INSUFFICIENCY; APPARENT VISCOSITY; INVIVO; FLOW; HEMATOCRIT; INVITRO; SHEAR; TUBES; DISAGGREGATION;
Keywords:
ARTERIOLAR VELOCITY; CAPILLARY DENSITY; DEXTRAN; MICROCIRCULATION; RED BLOOD CELL AGGREGATION; VISCOSITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
E. Vicaut et al., "RED-BLOOD-CELL AGGREGATION AND MICROCIRCULATION IN RAT CREMASTER MUSCLE", International journal of microcirculation, clinical and experimental, 14(1-2), 1994, pp. 14-21

Abstract

Using intravital microscopy of the rat cremaster muscle, we studied the effects of changing red blood cell (RBC) aggregation on RBC arteriolar velocity and perfused capillary density (PCD). To modify RBC aggregation, 2 and/or 10% dextran (molecular weights 40,000, 70,000 or 480,000) or fresh rat plasma was infused into adult male rats via a normovolemic hemodilution procedure. The high-molecular-weight dextrans (70,000 and 480,000) both induced RBC hyperaggregation associated with similar dose-dependent decreases in RBC arteriolar velocity (30 and 40% for dextran concentrations of 2 and 10%, respectively) and in PCD (35 and 37%, respectively, for the two concentrations). Conversely, with 40,000 molecular weight dextran or plasma, we observed a 30% increase inRBC arteriolar velocity, but no change in PCD or hyperaggregation. Intravenous injection of the antiaggregating drug troxerutin (10(-3) M),either before or after 2% dextran 70,000, significantly inhibited theeffects of this dextran on RBC arteriolar velocity and on PCD. We conclude that RBC hyperaggregation can lead to changes in both arteriolarvelocity and PCD and may, therefore, impair tissue oxygenation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:30:58