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Titolo:
GUILLAIN-BARRE-SYNDROME ASSOCIATED WITH C YTOMEGALOVIRUS-INFECTION AFTER RENAL-TRANSPLANTATION
Autore:
LLOVERAS JJ; LARRUE V; DELISLE MB; TACK I; ICART J; DUPRE C; THAT HT; DURAND D; SUC JM;
Indirizzi:
CHU RANGUEIL,SERV NEPHROL,UNITE TRANSPLANTAT ORGANES,1 AVE JEAN POULHES F-31054 TOULOUSE FRANCE CHU RANGUEIL,SERV VIROL F-31054 TOULOUSE FRANCE CHU RANGUEIL,SERV NEUROL F-31054 TOULOUSE FRANCE CHU RANGUEIL,SERV ANAT PATHOL F-31054 TOULOUSE FRANCE
Titolo Testata:
La Presse medicale
fascicolo: 21, volume: 23, anno: 1994,
pagine: 976 - 978
SICI:
0755-4982(1994)23:21<976:GAWCYA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
FRE
Soggetto:
IMMUNE-DEFICIENCY-SYNDROME; VIRUS INFECTION; POLYRADICULONEUROPATHY; NEUROPATHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Lloveras et al., "GUILLAIN-BARRE-SYNDROME ASSOCIATED WITH C YTOMEGALOVIRUS-INFECTION AFTER RENAL-TRANSPLANTATION", La Presse medicale, 23(21), 1994, pp. 976-978

Abstract

The Guillain-Barre syndrome associated with cytomegalovirus infectionis a recognized entity of unknown pathogenesis. We observed two characteristic cases with acute polyradiculoneuropathy which occurred afterrenal transplantation. Both patients fulfilled the diagnostic criteria for Guillain-Barre syndrome: tetraparesis with diffuse areflexia andmoderate sensorial signs, high protein level in cerebrospinal fluid without cellular reaction, slow or blocked nerve conduction and partialcure after several months delay. In two-thirds of such cases, the syndrome follows an episode of infection. Cytomegalovirus has been recognized as a possible association. The demyelinating polyradiculoneuropathy induced by cytomegalovirus has been reported essentially in immunodepressed patients infected with the human immunodeficiency virus in whom a pathogenic role for cytomegalovirus in peripheral nerves has beensuggested. In our two cases, the cytomegalovirus infection occurred before onset of the acute polyradiculoneuropathy. In both cases, specific IgM antibodies and clear IgG positivization occurred before the first signs of neurological impairment even though neither the virus nor specific antibodies could be concomitantly detected in the cerebrospinal fluid. Despite the frequency of cytomegalovirus infections in transplant recipients, to our knowledge, only 9 cases of Guillain-Barre syndrome after transplantation have been reported and the exact mechanismremains to be ascertained. These two cases suggest that the onset of the Guillain-Barre syndrome after renal transplantation was closely related to cytomegalovirus infection. Adequate measures should be taken to quickly diagnose such cases in order to instore rapid treatment forthe polyradiculoneuropathy. In addition, this particular situation ofpost-transplantation onset might help better understand the exact role of cytomegalovirus infection in the Guillain-Barre syndrome.

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Documento generato il 20/09/20 alle ore 04:30:04