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Titolo:
THE ROLE OF THE ENDOMETRIAL OXYTOCIN RECEPTOR IN DETERMINING THE LENGTH OF THE STERILE ESTROUS-CYCLE AND ENSURING MAINTENANCE OF LUTEAL FUNCTION IN EARLY-PREGNANCY IN RUMINANTS
Autore:
FLINT APF; LAMMING GE; STEWART HJ; ABAYASEKARA DRE;
Indirizzi:
UNIV NOTTINGHAM,DEPT ENVIRONM SCI & PHYSIOL,SUTTON BONINGTON CAMPUS LOUGHBOROUGH LE12 5RD LEICS ENGLAND ZOOL SOC LONDON,INST ZOOL LONDON NW1 4RY ENGLAND
Titolo Testata:
Philosophical transactions-Royal Society of London. Biological sciences
fascicolo: 1309, volume: 344, anno: 1994,
pagine: 291 - 304
SICI:
0962-8436(1994)344:1309<291:TROTEO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVINE CORPUS-LUTEUM; CONCEPTUS SECRETORY PROTEINS; MATERNAL RECOGNITION; MESSENGER-RNA; TROPHOBLAST PROTEIN-1; OVARIAN OXYTOCIN; GENE-EXPRESSION; ESTROUS-CYCLE; PROSTAGLANDIN-F2-ALPHA SECRETION; NEUROPHYSIN PROHORMONE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
104
Recensione:
Indirizzi per estratti:
Citazione:
A.P.F. Flint et al., "THE ROLE OF THE ENDOMETRIAL OXYTOCIN RECEPTOR IN DETERMINING THE LENGTH OF THE STERILE ESTROUS-CYCLE AND ENSURING MAINTENANCE OF LUTEAL FUNCTION IN EARLY-PREGNANCY IN RUMINANTS", Philosophical transactions-Royal Society of London. Biological sciences, 344(1309), 1994, pp. 291-304

Abstract

The oxytocin receptor, a seven transmembrane domain, G protein-linkedreceptor molecule, plays a central role in determining the endocrine function of the ruminant uterine endometrium. During nonpregnant cycles the control of this molecule by circulating steroid hormones leads to regression of the corpora lutea. The kinetics of the mechanisms involved determine the time at which luteolysis occurs, and therefore the length of the oestrous cycle. In pregnancy, secretions of the trophoblast block endometrial oxytocin receptor gene expression and lead to luteal maintenance. An understanding of the molecular mechanisms involved in the steroidal control of oxytocin receptor gene expression will provide an explanation for the relative constancy of oestrous cycle lengths in non-pregnant animals. Unravelling the way in which trophoblastproducts block expression of the oxytocin receptor gene will lead to a better understanding of the reasons for the high rate of embryonic loss in domestic ruminants.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 16:20:03