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Titolo:
ANALYSIS OF IMMUNOGLOBULIN ISOTYPE LEVELS IN ACUTE PNEUMOCOCCAL BACTEREMIA AND IN CONVALESCENCE
Autore:
EKDAHL K; ROLLOF J; OXELIUS VA; ENGELLAU J; BRACONIER JH;
Indirizzi:
UNIV LUND HOSP,DEPT INFECT DIS S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT PEDIAT S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT ONCOL S-22185 LUND SWEDEN
Titolo Testata:
European journal of clinical microbiology & infectious diseases
fascicolo: 5, volume: 13, anno: 1994,
pagine: 374 - 378
SICI:
0934-9723(1994)13:5<374:AOIILI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPSULAR POLYSACCHARIDE ANTIGEN; COMMUNITY-ACQUIRED PNEUMONIA; IGG-SUBCLASS DEFICIENCY; INFECTIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
K. Ekdahl et al., "ANALYSIS OF IMMUNOGLOBULIN ISOTYPE LEVELS IN ACUTE PNEUMOCOCCAL BACTEREMIA AND IN CONVALESCENCE", European journal of clinical microbiology & infectious diseases, 13(5), 1994, pp. 374-378

Abstract

In 48 patients with a history of a pneumococcal bacteremia, serum taken during the acute phase of the infection was analyzed for IgG and IgG subclasses. Once the patients were free of infection, a serum samplewas analyzed for IgG, IgG subclasses, IgA and IgM. In an additional 20 patients, it was only possible to analyze serum from the infection-free phase. Seventeen of 48 (35 %) patients had reduced levels of totalIgG or of one or more of the IgG subclasses during acute disease. Of the 48 patients in whom both acute phase and infection-free phase serum were analyzed, values of IgG (p < 0.001), IgG1 (p < 0.001), IgG2 (p < 0.001), IgG3 (p < 0.01) and IgG4 (p < 0.01) were decreased during the acute infection. During the infection-free phase, 12 of 68 (18 %) patients had a recognizable immunodeficiency, including two patients with common variable immunodeficiency. Routine screening for immunoglobulins during the infection-free period could result in the discovery of previously unrecognized immunoglobulin deficiencies in patients with ahistory of bacteremic pneumococcal infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:08:58