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Titolo:
INADEQUATE TSH SECRETION - CLINICAL-FEATU RES, DIAGNOSTIC-CRITERIA AND THERAPEUTIC POSSIBILITIES
Autore:
CAIXAS A; INFIESTA F; BALSELLS M; RODRIGUEZESPINOSA J; SCHWARZSTEIN D; WEBB SM;
Indirizzi:
HOSP SANTA CRUZ & SAN PABLO,SERV ENDOCRINOL & NUTR,PARE CLARET 167 E-08025 BARCELONA SPAIN HOSP SANTA CRUZ & SAN PABLO,SERV ENDOCRINOL & NUTR,PARE CLARET 167 E-08025 BARCELONA SPAIN HOSP SANTA CRUZ & SAN PABLO,SERV BIOQUIM E-08025 BARCELONA SPAIN UNIV AUTONOMA BARCELONA BARCELONA SPAIN HOSP CREU ROJA DE BARCELONA,SERV ENDOCRINOL & NUTR BARCELONA SPAIN
Titolo Testata:
Medicina Clinica
fascicolo: 20, volume: 102, anno: 1994,
pagine: 776 - 780
SICI:
0025-7753(1994)102:20<776:ITS-CR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
SPA
Soggetto:
THYROTROPIN-INDUCED HYPERTHYROIDISM; SELECTIVE PITUITARY RESISTANCE; 3,5,3'-TRIIODOTHYROACETIC ACID; INAPPROPRIATE SECRETION; THYROID-HORMONE; ADENOMAS; SUBUNIT; ALPHA;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
A. Caixas et al., "INADEQUATE TSH SECRETION - CLINICAL-FEATU RES, DIAGNOSTIC-CRITERIA AND THERAPEUTIC POSSIBILITIES", Medicina Clinica, 102(20), 1994, pp. 776-780

Abstract

Inadequate secretion of TSH (IST) is a disorder which is diagnosed more frequently and earlier after the introduction of new immunoassay techniques which can distinguish between normal and suppressed TSH levels. For diagnosis high or unsupressed TSH in required in the presence of elevated levels of the thyroid hormones. Its etiology may be tumoral(TSH secreting pituitary adenoma) or non tumoral due to pituitary or generalized resistence to the thyroid hormones. Differential diagnosisbetween both etiologies is not easy, and several tests have been proposed but are not always discriminatory. Five cases of IST are presented in whom the diagnostic, clinical and therapeutic criteria have been analyzed. The cases of neoplastic IST (patients n.o 3, 4, and 5) showed a loss in circadian rhythm of TSH and absence of suppression with triiodothyronin (T3), 3.5-diiodo 4-(3'-iodine 4'-hydroxyphenoxi) phenylacetic acid (TRIAC) and with bromocryptine. The circadian rhythm of TSHwas maintained in the non neoplastic IST (patients n.o 1 and 2) as was suppressed with T3, TRIAC and bromocryptine. The subunit-alpha/TSH quotient and TSH response to TRH were variable with no stimulation being observed with methoclopramide in any case. Upon the demonstration ofunsupressed circulating TSH in the presence of biochemical hyperthyroidism, IST should be suspected to avoid erroneous diagnosis and treatments. Differentiation between neoplastic and non neoplastic origin maybe difficult since the biochemical and neuropharmacologic parameters are not always discriminatory.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:22:27