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Titolo:
RETROBULBAR T-CELLS FROM PATIENTS WITH GRAVES OPHTHALMOPATHY ARE CD8+AND SPECIFICALLY RECOGNIZE AUTOLOGOUS FIBROBLASTS
Autore:
GRUBECKLOEBENSTEIN B; TRIEB K; SZTANKAY A; HOLTER W; ANDERL H; WICK G;
Indirizzi:
AUSTRIAN ACAD SCI,INST BIOMED AGING RES,RENNWEG 10 A-6020 INNSBRUCK AUSTRIA INNSBRUCK UNIV,DEPT PLAST SURG A-6020 INNSBRUCK AUSTRIA SFI,VIENNA INT RES COOPERAT CTR A-1235 VIENNA AUSTRIA INNSBRUCK UNIV,SCH MED,INST GEN & EXPTL PATHOL A-6020 INNSBRUCK AUSTRIA
Titolo Testata:
The Journal of clinical investigation
fascicolo: 6, volume: 93, anno: 1994,
pagine: 2738 - 2743
SICI:
0021-9738(1994)93:6<2738:RTFPWG>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAT-SHOCK PROTEINS; HUMAN FOAMY VIRUS; GRAVES-DISEASE; EXTRATHYROIDAL MANIFESTATIONS; RETROOCULAR FIBROBLASTS; EYE DISEASE; ANTIBODIES; TISSUE; HYPERTHYROIDISM; LOCALIZATION;
Keywords:
GRAVES DISEASE; OPHTHALMOPATHY; T LYMPHOCYTES; FIBROBLASTS; CYTOKINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
B. Grubeckloebenstein et al., "RETROBULBAR T-CELLS FROM PATIENTS WITH GRAVES OPHTHALMOPATHY ARE CD8+AND SPECIFICALLY RECOGNIZE AUTOLOGOUS FIBROBLASTS", The Journal of clinical investigation, 93(6), 1994, pp. 2738-2743

Abstract

Graves' ophthalmopathy is an autoimmune condition characterized by T cell infiltration of the retrobulbar tissue. Phenotypic and functionalanalysis of these infiltrating cells may provide insight into the pathogenesis of the disease. IL-2-responsive cells were therefore grown out of the retrobulbar tissue from two patients with severe Graves' ophthalmopathy undergoing orbital decompression surgery, and sis T cell lines were established and characterized. They consisted predominantly of CD8(+)CD45RO(+) cells and secreted IL-4, IFN-gamma, and IL-10 upon activation. When screened for their antigen reactivity, all lines proliferated in response to stimulation with autologous retrobulbar fibroblasts in an HLA class I-restricted manner, but did not recognize autologous peripheral blood mononuclear cells, crude eye muscle extract, allogeneic cells, or purified protein derivate of Mycobacterium tuberculosis. In contrast, PBMC from the same patients responded readily to purified protein derivate of Mycobacterium tuberculosis and allogeneic PBMC, but did not recognize autologous fibroblasts. Interestingly, onlyone of the six retrobulbar T cell lines displayed cytotoxicity towards its specific target cell population. These results suggest that the retrobulbar fibroblasts are a major T cell target in Graves' ophthalmopathg. Pronounced cytokine production in the absence of target cell cytotoxicity may explain fibroblast proliferation. glycosaminoglycan secretion, and secondary eye muscle enlargement in this condition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 07:59:40