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Titolo:
TEMPORAL ANALYSIS OF THE ANTIBODY-RESPONSE TO HIV ENVELOPE PROTEIN INHIV-INFECTED LABORATORY WORKERS
Autore:
PINCUS SH; MESSER KG; NARA PL; BLATTNER WA; COLCLOUGH G; REITZ M;
Indirizzi:
NIAID,ROCKY MT LABS,MICROBIAL STRUCT & FUNCT LAB HAMILTON MT 59840 NCI BETHESDA MD 20892 FREDERICK CANC RES & DEV CTR FREDERICK MD 21702 RES TRIANGLE INST ROCKVILLE MD 20852
Titolo Testata:
The Journal of clinical investigation
fascicolo: 6, volume: 93, anno: 1994,
pagine: 2505 - 2513
SICI:
0021-9738(1994)93:6<2505:TAOTAT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; NEUTRALIZING ANTIBODIES; TYPE-1 GP120; CELLS; INFECTIVITY; GENERATION; EPITOPE; DOMAIN; GP160; ASSAY;
Keywords:
HIV; AIDS; ANTIBODY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
S.H. Pincus et al., "TEMPORAL ANALYSIS OF THE ANTIBODY-RESPONSE TO HIV ENVELOPE PROTEIN INHIV-INFECTED LABORATORY WORKERS", The Journal of clinical investigation, 93(6), 1994, pp. 2505-2513

Abstract

Three laboratory workers have been infected with the IIIB strain of HIV; their antibody response to HIV has been studied in serial serum specimens. Because the infecting virus is known, the fine specificity ofthe antibody response was studied on the homologous strain of HIV. Anti-p17, anti-p24, anti-gp160, CD4/gp120 blocking and neutralizing antibodies developed in parallel. Epitope mapping of the anti-gp160 response indicated several regions that consistently induced an antibody response. Serum contained antibody which reacted with V3-specific peptides corresponding to the very tip of the loop and crossreactivity was seen with V3 loop peptides from other sequence divergent strains of HIV. Antibody to the V1 loop was produced at levels comparable with that seen for the V3-loop. Anti-V1 neutralized HIV with a titration curve equivalent to an anti-V3 monoclonal antibody. Because the infecting virus is known and serial reisolates have been obtained, we explored the relationship between production of antibody to a given epitope and mutation in the virus. The data suggest that an association exists, but donot clearly indicate that antibody drives the selection for mutant viruses. The findings presented here provide a fine specificity analysisof the evolution of the antibody response to HIV in greater detail than has previously been performed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:49:31