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Titolo:
PREPROTEINS OF CHLOROPLAST ENVELOPE INNER MEMBRANE CONTAIN TARGETING INFORMATION FOR RECEPTOR-DEPENDENT IMPORT INTO FUNGAL MITOCHONDRIA
Autore:
BRINKS S; FLUGGE UI; CHAUMONT F; BOUTRY M; EMMERMANN M; SCHMITZ U; BECKER K; PFANNER N;
Indirizzi:
UNIV FREIBURG,INST BIOCHEM,HERMANN HERDER STR 7 D-79104 FREIBURG GERMANY UNIV FREIBURG,INST BIOCHEM D-79104 FREIBURG GERMANY UNIV WURZBURG,JULIUS VON SACHS INST BIOWISSENSCH D-97082 WURZBURG GERMANY UNIV CATHOLIQUE LOUVAIN,UNITE BIOCHIM PHYSIOL B-1348 LOUVAIN BELGIUM INST GENBIOL FORSCH D-14195 BERLIN GERMANY UNIV MUNICH,INST PHYSIOL CHEM D-80336 MUNICH GERMANY
Titolo Testata:
The Journal of biological chemistry
fascicolo: 23, volume: 269, anno: 1994,
pagine: 16478 - 16485
SICI:
0021-9258(1994)269:23<16478:POCEIM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN IMPORT; YEAST MITOCHONDRIA; PRECURSOR PROTEINS; PHOSPHATE TRANSLOCATOR; ENDOPLASMIC-RETICULUM; PROCESSING PEPTIDASE; SPINACH-CHLOROPLASTS; INTERMEMBRANE SPACE; PLANT-MITOCHONDRIA; TRANSIT PEPTIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
S. Brinks et al., "PREPROTEINS OF CHLOROPLAST ENVELOPE INNER MEMBRANE CONTAIN TARGETING INFORMATION FOR RECEPTOR-DEPENDENT IMPORT INTO FUNGAL MITOCHONDRIA", The Journal of biological chemistry, 269(23), 1994, pp. 16478-16485

Abstract

The amino-terminal transit sequences of two preproteins destined for the chloroplast inner envelope membrane show similarities to mitochondrial presequences in the prevalence of positive charges and the potential formation of an amphipathic alpha-helix. We studied if these preproteins could be imported into mitochondria and found a low, yet significant import into isolated plant mitochondria. The plant mitochondria were previously shown not to import precursors of chloroplast stromal or thylakoidal proteins. To analyze the specificity of import into mitochondria we used the established import systems of fungal mitochondria. The envelope preproteins were efficiently imported into Saccharomyces cerevisiae or Neurospora crassa mitochondria. Their import showed the characteristics of specific mitochondrial protein uptake, includinga requirement for the main receptor MOM19 (mitochondrial outer membrane protein of 19 kDa) and a membrane potential across the inner membrane, and depended on the presence of the chloroplast transit sequence. We conclude that some chloroplast transit sequences contain sufficientinformation for specific interaction with mitochondrial import receptors (at least from fungal sources).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:07:00