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Titolo:
LEWIS PHENOTYPE, SECRETOR STATUS, AND CELIAC-DISEASE
Autore:
DICKEY W; WYLIE JDC; COLLINS JSA; PORTER KG; WATSON RGP; MCLOUGHLIN JC;
Indirizzi:
QUEENS UNIV BELFAST,INST CLIN SCI,DEPT MED,GROSVENOR RD BELFAST BT12 6BJ ANTRIM NORTH IRELAND ROYAL VICTORIA HOSP BELFAST BT12 6BA NORTH IRELAND MATER HOSP BELFAST ANTRIM NORTH IRELAND
Titolo Testata:
Gut
fascicolo: 6, volume: 35, anno: 1994,
pagine: 769 - 770
SICI:
0017-5749(1994)35:6<769:LPSSAC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELIAC-DISEASE; ADENOVIRUS-12; INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
W. Dickey et al., "LEWIS PHENOTYPE, SECRETOR STATUS, AND CELIAC-DISEASE", Gut, 35(6), 1994, pp. 769-770

Abstract

Patients who cannot secrete ABO and Lewis blood group antigens into body fluids, an ability controlled by a single gene on chromosome 19, are known to be at increased risk of certain autoimmune diseases associated with human leucocyte antigen (HLA) markers. This study investigated the possibility of an association with coeliac disease using red cell Lewis (Le) blood group phenotype to infer secretor status. Among 73patients with coeliac disease who had Le a or b antigen, 48% were nonsecretors (Le a+ b-) compared with 27% of 137 blood donors (p = 0.004:odds ratio 2.49, 95% confidence intervals 1.37 to 4.51) and 26% of 62medical and nursing staff controls (p = 0.014: odds ratio 2.65, 95% confidence intervals 1.27 to 5.50). Clinical characteristics did not differ between secretors and nonsecretors with coeliac disease. Thus, the nonsecretor state is significantly associated with coeliac disease, suggesting that genes on chromosome 19 may directly or indirectly participate in conferring susceptibility.

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Documento generato il 25/11/20 alle ore 10:02:25