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Titolo:
LONG-TERM THYMOPENTIN TREATMENT IN SYSTEMIC SCLERODERMA
Autore:
DANESE C; ZAVATTARO E; CALISI L; MARCIANO F; PEREGO MA;
Indirizzi:
UNIV ROMA LA SAPIENZA,MED CLIN 2 I-00185 ROME ITALY
Titolo Testata:
Current medical research and opinion
fascicolo: 4, volume: 13, anno: 1994,
pagine: 195 - 201
SICI:
0300-7995(1994)13:4<195:LTTISS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCLEROSIS; CELLS;
Keywords:
THYMOPENTIN; SCLERODERMA, SYSTEMIC; LYMPHOCYTE SUBSETS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
C. Danese et al., "LONG-TERM THYMOPENTIN TREATMENT IN SYSTEMIC SCLERODERMA", Current medical research and opinion, 13(4), 1994, pp. 195-201

Abstract

A study was carried out to investigate whether thymopentin treatment is capable of inducing changes in the immunological status of patientswith systemic scleroderma and to compare any such changes with modifications in clinical condition. Nine patients were given thymopentin, 1ml in 10 ml saline solution, by slow intravenous infusion 3-times weekly for 5 weeks (cycle). The cycles were repeated at 3-month intervals. Treatment duration ranged from 1 to 5 years. Blood samples were drawn at the beginning and at the end of each cycle and the patients' lymphocytic sub-populations were examined A control group of 9 comparable healthy subjects were similarly tested Data analysis showed that a statistically significant decrease of CD16+ and CD25+ lymphocytes compared to pretreatment was already apparent at the end of the first thymopentin treatment cycle. An improvement was found in the clinical condition of 7 of the 9 patients at the end of the follow-up period with a significant correction of unbalanced lymphocytic subsets.

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Documento generato il 11/08/20 alle ore 21:31:50