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Titolo:
MOTIVATION PRODUCED BY MORPHINE AND FOOD IS ISOMORPHIC - APPROACHES TO SPECIFIC MOTIVATIONAL STIMULI ARE LEARNED
Autore:
NADER K; VANDERKOOY D;
Indirizzi:
UNIV TORONTO,FAC MED,DEPT ANAT,NEUROBIOL RES GRP TORONTO M5S 1A8 ON CANADA
Titolo Testata:
Psychobiology
fascicolo: 1, volume: 22, anno: 1994,
pagine: 68 - 76
SICI:
0889-6313(1994)22:1<68:MPBMAF>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDITIONED PLACE PREFERENCES; WATER-INTAKE; RAT PUPS; AMPHETAMINE; BEHAVIOR; DEPRIVATION; REINFORCEMENT; NEUROLEPTICS; ANHEDONIA; REWARD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
73
Recensione:
Indirizzi per estratti:
Citazione:
K. Nader e D. Vanderkooy, "MOTIVATION PRODUCED BY MORPHINE AND FOOD IS ISOMORPHIC - APPROACHES TO SPECIFIC MOTIVATIONAL STIMULI ARE LEARNED", Psychobiology, 22(1), 1994, pp. 68-76

Abstract

Using an unbiased place preference paradigm, opiate-naive rats were conditioned as follows: one side was paired with 18-h food deprivation,and the other environment was paired with 18-h food deprivation and morphine (20 mg/kg i.p.). On the test day, animals showed a large preference for the environment paired with hunger and morphine. The acquisition of this preference was unaffected by bilateral ibotenic lesions of the brainstem tegmental pedunculopontine (TPP) nucleus, but was completely blocked by pretreatment with alpha-flupentixol (0.8 mg/kg i.p.). The failure of TPP lesions, which have previously been shown to abolish the motivational effects of morphine in drug-naive animals, to affect the present preferences in food-deprived rats suggests that morphine is not producing its normal (drug-naive) motivational effects. We suggest that morphine can substitute for the dopamine-mediated, motivational effects of food in a food-deprived animal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 07:14:26