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Titolo:
INSULIN ATTENUATES SCOPOLAMINE-INDUCED MEMORY DEFICITS
Autore:
MESSIER C; DESTRADE C;
Indirizzi:
UNIV OTTAWA,SCH PSYCHOL,ROOM 215 OTTAWA K1N 6N5 ON CANADA UNIV BORDEAUX 1 F-33405 TALENCE FRANCE
Titolo Testata:
Psychobiology
fascicolo: 1, volume: 22, anno: 1994,
pagine: 16 - 21
SICI:
0889-6313(1994)22:1<16:IASMD>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICAL CHOLINERGIC ACTIVATION; BLOOD-BRAIN-BARRIER; 8-ARM RADIAL MAZE; GLUCOSE ENHANCEMENT; ALZHEIMERS-DISEASE; ELDERLY HUMANS; ACETYLCHOLINE SYNTHESIS; SPATIAL DISCRIMINATION; HIPPOCAMPAL; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
C. Messier e C. Destrade, "INSULIN ATTENUATES SCOPOLAMINE-INDUCED MEMORY DEFICITS", Psychobiology, 22(1), 1994, pp. 16-21

Abstract

Most of the agents that attenuate scopolamine-induced amnesia can also improve memory when injected alone. We report here that insulin can attenuate scopolamine-induced amnesia even though insulin per se has little memory-improving action. Male Balb/c mice were trained in an appetitive barpressing task. Immediately after the mice had completed 15 trials, scopolamine hydrochloride was injected (0.1, 0.2, 0.3, 0.6, 1.0 mg/kg i.p.) in conjunction with either saline or insulin (0.8 IU/kg,subcutaneously). The animals' retention of the training was tested the next day. The 0.6- and 1.0-mg/kg doses of scopolamine (but not the lower doses) produced an amnesia for the barpressing task training. This amnesia was significantly reduced by an insulin injection given at the same time as the scopolamine injection. However, the injection of insulin alone had no effect on memory processes. These results show that insulin can protect from scopolamine amnesia. Possibly, insulin modulates scopolamine-induced amnesia directly through an action on insulin receptors in the brain.

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Documento generato il 29/11/20 alle ore 00:41:05