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Titolo:
SECRETORY IGA ANTIBODIES TO CRYPTOSPORIDIUM-PARVUM IN AIDS PATIENTS WITH CHRONIC CRYPTOSPORIDIOSIS
Autore:
COZON G; BIRON F; JEANNIN M; CANNELLA D; REVILLARD JP;
Indirizzi:
HOP EDOUARD HERRIOT,INSERM,U80,IMMUNOL LAB,HERRIOT PAVILLON P F-69437LYON 03 FRANCE HOP CROIX ROUSSE,SERV MALAD INFECT LYON FRANCE
Titolo Testata:
The Journal of infectious diseases
fascicolo: 3, volume: 169, anno: 1994,
pagine: 696 - 699
SICI:
0022-1899(1994)169:3<696:SIATCI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERIMMUNE BOVINE COLOSTRUM; INFECTION; DIARRHEA; CELLS; MICE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
G. Cozon et al., "SECRETORY IGA ANTIBODIES TO CRYPTOSPORIDIUM-PARVUM IN AIDS PATIENTS WITH CHRONIC CRYPTOSPORIDIOSIS", The Journal of infectious diseases, 169(3), 1994, pp. 696-699

Abstract

Immune mechanisms that may control Cryptosporidium parvum infection remain unknown. The role of T cell-mediated immunity is suggested by the chronic disease observed in AIDS patients and in athymic or CD4(+) Tcell-depleted mice. The role of specific antibodies is also unclear. This study sought to determine serum and secretory antibodies to C. parvum in patients infected with human immunodeficiency virus type 1 (HIV-1) with or without chronic cryptosporidiosis. C. parvum-specific antibodies and specific secretory antibodies were determined by ELISA in saliva and sera from 50 HIV-1-infected patients, 27 healthy adults, and 21 healthy children. Despite lower CD4(+) lymphocyte counts, patients with chronic cryptosporidiosis had increased levels of C. parvum-specific antibodies in saliva and serum and higher specific secretory antibody levels in saliva than did controls. Persistance of protracted diarrhea despite high levels of both serum and secretory antibodies suggests that specific secretory antibodies are not sufficient to control this protozoan parasite infection of intestinal mucosa.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:30:46