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Titolo:
RECOMBINANT GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR ENHANCESTHE EFFECTS OF ANTIBIOTICS AGAINST MYCOBACTERIUM-AVIUM COMPLEX INFECTION IN THE BEIGE MOUSE MODEL
Autore:
BERMUDEZ LE; MARTINELLI J; PETROFSKY M; KOLONOSKI P; YOUNG LS;
Indirizzi:
CALIF PACIFIC MED CTR,RES INST,KUZELL INST ARTHRIT & INFECT DIS,2200 WEBSTER ST,SUITE 305 SAN FRANCISCO CA 94115
Titolo Testata:
The Journal of infectious diseases
fascicolo: 3, volume: 169, anno: 1994,
pagine: 575 - 580
SICI:
0022-1899(1994)169:3<575:RGCFE>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CULTURED HUMAN MACROPHAGES; CELLS; INVITRO; GROWTH; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
L.E. Bermudez et al., "RECOMBINANT GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR ENHANCESTHE EFFECTS OF ANTIBIOTICS AGAINST MYCOBACTERIUM-AVIUM COMPLEX INFECTION IN THE BEIGE MOUSE MODEL", The Journal of infectious diseases, 169(3), 1994, pp. 575-580

Abstract

Previous studies have shown that recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates human and murine macrophages to inhibit growth and kill intracellularly. This study shows the effect of GM-CSF on Mycobacterium avium complex (MAC) infection in vivousing a C57BL/6 beige mouse model of disseminated MAC infection. Furthermore, it examined the activity of the combination of GM-CSF and amikacin or azithromycin, two antimicrobials active against MAC, on the survival of MAC within macrophages in vitro and in the mouse model of disseminated infection. Although GM-CSF (25 mg/kg) induced mycobactericidal and mycobacteriostatic activity in macrophages in vitro and in vivo, the combination of GM-CSF and amikacin (50 mg/kg) or azithromycin (250 mg/kg) was associated with a significant increase in killing of MAC both within cultured macrophages and in the beige mouse model. Therefore, a significant reduction in the number of viable bacteria was observed in blood, liver, and spleen of mice treated with a combination of GM-CSF and azithromycin or amikacin compared with control mice and those treated with GM-CSF or antimicrobials alone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 06:14:49