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Titolo:
DECOMPOSITION OF CISPLATIN IN AQUEOUS-SOLUTIONS CONTAINING CHLORIDES BY ULTRASONIC ENERGY AND TIGHT
Autore:
MACKA M; BORAK J; SEMENKOVA L; KISS F;
Indirizzi:
UNIV TASMANIA,DEPT CHEM,GPO BOX 252C HOBART TAS 7001 AUSTRALIA LACHEMA AS,FINE CHEM RES INST CR-62133 BRNO CZECH REPUBLIC
Titolo Testata:
Journal of pharmaceutical sciences
fascicolo: 6, volume: 83, anno: 1994,
pagine: 815 - 818
SICI:
0022-3549(1994)83:6<815:DOCIAC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; PLATINUM COMPLEXES; ELECTROCHEMICAL DETECTION; HUMAN-PLASMA; STABILITY; CIS-DICHLORODIAMMINEPLATINUM(II); CIS-DIAMMINEDICHLOROPLATINUM(II); METABOLITES; EXCHANGERS; SEPARATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
M. Macka et al., "DECOMPOSITION OF CISPLATIN IN AQUEOUS-SOLUTIONS CONTAINING CHLORIDES BY ULTRASONIC ENERGY AND TIGHT", Journal of pharmaceutical sciences, 83(6), 1994, pp. 815-818

Abstract

Decomposition of cisplatin in an aqueous 0.15 M chloride solution by diffuse daylight, by monochromatic light, and by ultrasonic energy wasstudied using a new HPLC method. The relative sensitivity of cisplatin to light copies the curve of the absorption spectrum of cisplatin with maximum at ca. 300 nm; however, any light below 500 nm must be avoided. Sonication also leads to a rapid decomposition of cisplatin. Irradiation by diffuse daylight or sonication of the cisplatin solutions for 5 min leads to ca. 1% amminetrichloroplatinate(II). Using HPLC analysis with diode-array spectrophotometric detection, the main decomposition product was identified as amminetrichloroplatinate(II).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 13:51:52