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Titolo:
INTERLEUKIN-1 AUGMENTS THE DIMINISHED INTERLEUKIN-2 MESSENGER-RNA EXPRESSION AND PROLIFERATIVE RESPONSE OF NEONATAL T-LYMPHOCYTES TO ANTI-CD2 ANTIBODIES
Autore:
HASSAN J; REEN DJ;
Indirizzi:
OUR LADYS HOSP SICK CHILDREN,CHILDRENS RES CTR DUBLIN 12 IRELAND
Titolo Testata:
Scandinavian journal of immunology
fascicolo: 6, volume: 39, anno: 1994,
pagine: 597 - 601
SICI:
0300-9475(1994)39:6<597:IATDIM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD MONONUCLEAR-CELLS; HUMAN CORD BLOOD; INTERFERON-PRODUCTION; GAMMA PRODUCTION; JUN ENCODES; AP-1; PROMOTER; ANTIGEN; SUBSETS; INDUCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
J. Hassan e D.J. Reen, "INTERLEUKIN-1 AUGMENTS THE DIMINISHED INTERLEUKIN-2 MESSENGER-RNA EXPRESSION AND PROLIFERATIVE RESPONSE OF NEONATAL T-LYMPHOCYTES TO ANTI-CD2 ANTIBODIES", Scandinavian journal of immunology, 39(6), 1994, pp. 597-601

Abstract

Expression of IL-2 mRNA by unstimulated and stimulated purified T cells and mononuclear cells from adult and cord blood was investigated inan attempt to better understand the underlying defective neonatal host immune defense system. Using RNA dot-blot analysis, IL-2 mRNA expression in anti-CD2-stimulated neonatal T cells revealed significantly reduced levels when compared to adult T cells (P < 0.01). Purified neonatal T cells also showed a significantly reduced proliferative responseto anti-CD2 antibodies (P < 0.01). Addition of IL-1 beta enhanced thehyporesponsiveness of neonatal T cells at both the level of proliferation and IL-2 mRNA expression. Unseparated mononuclear cells from adult and cord blood revealed similar IL-2 mRNA levels and proliferation when activated by anti-CD2 stimulation. The reduced IL-2 mRNA expression observed in neonatal T cells may explain, in part, the difference inhost defense between the newborn and adult during states of increaseddemand such as infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 12:17:56