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Titolo:
PHARMACOTHERAPY OF DELUSIONAL DEPRESSION - EXPERIENCE WITH COMBINATIONS OF ANTIDEPRESSANTS WITH THE NEUROLEPTICS ZOTEPINE AND HALOPERIDOL
Autore:
WOLFERSDORF M; KONIG F; STRAUB R;
Indirizzi:
UNIV ULM,WEISSENAU PSYCHIAT HOSP,DEPT PSYCHIAT 1,DIV ACUTE PSYCHIAT 2D-88190 RAVENSBURG GERMANY
Titolo Testata:
Neuropsychobiology
fascicolo: 4, volume: 29, anno: 1994,
pagine: 189 - 193
SICI:
0302-282X(1994)29:4<189:PODD-E>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-BLIND TRIAL;
Keywords:
DELUSIONAL DEPRESSION; ANTIDEPRESSIVE; NEUROLEPTIC COMBINATION; BUTYROPHENONES; ZOTEPINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
M. Wolfersdorf et al., "PHARMACOTHERAPY OF DELUSIONAL DEPRESSION - EXPERIENCE WITH COMBINATIONS OF ANTIDEPRESSANTS WITH THE NEUROLEPTICS ZOTEPINE AND HALOPERIDOL", Neuropsychobiology, 29(4), 1994, pp. 189-193

Abstract

The combination of an antidepressant with a neuroleptic is standard pharmacotherapy for delusional depression today. The neuroleptics used are rarely specified: occasionally haloperidol or perphenazine are mentioned. In two different open-treatment studies, consecutively admitted delusional depressed inpatients received a butyrophenone [haloperidol, bromperidol, approximately 10 mg/day (n = 16)] or zotepine [150-200mg/day (n = 15)] as a neuroleptic in combination with a tri- or tetracyclic antidepressant (amitriptyline, maprotiline, 150 mg/day). There was a significant improvement in both groups in the sum score of the Hamilton depression scale (24-item version), in a subscore of so-calleddelusional items (items 2, 17, 19, 20, 23, and 24 together), in the subscore of remaining items and also in most single items such as mood,inhibition, agitation, feelings of guilt or hopelessness.

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Documento generato il 20/01/20 alle ore 16:05:38