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Titolo:
HERPES-SIMPLEX ENCEPHALITIS IN THE TEMPORAL CORTEX AND LIMBIC SYSTEM AFTER TRIGEMINAL NERVE INOCULATION
Autore:
BARNETT EM; JACOBSEN G; EVANS G; CASSELL M; PERLMAN S;
Indirizzi:
UNIV IOWA,DEPT PEDIAT,ML207 IOWA CITY IA 52242 UNIV IOWA,DEPT PEDIAT IOWA CITY IA 52242 UNIV IOWA,COLL DENT,NEUROSCI PROGRAM IOWA CITY IA 52242 UNIV IOWA,DEPT ANAT IOWA CITY IA 52242
Titolo Testata:
The Journal of infectious diseases
fascicolo: 4, volume: 169, anno: 1994,
pagine: 782 - 786
SICI:
0022-1899(1994)169:4<782:HEITTC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRUS TYPE-1; CENTRAL PROJECTIONS; TRANSNEURONAL TRANSPORT; AFFERENT NEURONS; RAT; MICE; LOCALIZATION; ORGANIZATION; PATHWAYS; GANGLION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
E.M. Barnett et al., "HERPES-SIMPLEX ENCEPHALITIS IN THE TEMPORAL CORTEX AND LIMBIC SYSTEM AFTER TRIGEMINAL NERVE INOCULATION", The Journal of infectious diseases, 169(4), 1994, pp. 782-786

Abstract

Herpes simplex virus type 1 causes an encephalitis in humans that is primarily restricted to the temporal lobe and limbic system. The distribution of lesions suggests that virus enters the brain from a single site and then spreads transneuronally to infect connected structures. Two obvious sites of potential viral entry are the olfactory and trigeminal nerves. Trigeminal nerve entry is more likely because it innervates the oral cavity, a common site of initial infection, and the trigeminal ganglion is the most common site of viral latency. In previous reports, however, experimental trigeminal nerve infection has never ledto the pattern of disease observed in humans. By directly inoculatingvirus into the murine tooth pulp, the mandibular division of the trigeminal nerve was selectively infected. This division, which innervatesthe oral cavity, is the one most commonly infected in humans. Intrapun inoculation led to an encephalitis primarily affecting the temporal cortex and limbic system. Thus, spread via the trigeminal nerve provides an explanation for the distribution of herpes simplex virus observed in the human encephalitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 21:49:24