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Titolo:
FREQUENCY-DISTRIBUTION OF CYTOMEGALOVIRUS ENVELOPE GLYCOPROTEIN GENOTYPES IN BONE-MARROW TRANSPLANT RECIPIENTS
Autore:
FRIES BC; CHOU SW; BOECKH M; TOROKSTORB B;
Indirizzi:
FRED HUTCHINSON CANC RES CTR,1124 COLUMBIA ST SEATTLE WA 98104 FRED HUTCHINSON CANC RES CTR SEATTLE WA 98104 UNIV WASHINGTON,SCH MED SEATTLE WA 00000 VET ADM MED CTR SEATTLE WA 00000 OREGON HLTH SCI UNIV PORTLAND OR 00000
Titolo Testata:
The Journal of infectious diseases
fascicolo: 4, volume: 169, anno: 1994,
pagine: 769 - 774
SICI:
0022-1899(1994)169:4<769:FOCEGG>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRUS GLYCOPROTEIN; STRAIN TOWNE; ANTIBODY-RESPONSE; INFECTION; GANCICLOVIR; COMPLEX; DISEASE; EXPRESSION; GB; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
B.C. Fries et al., "FREQUENCY-DISTRIBUTION OF CYTOMEGALOVIRUS ENVELOPE GLYCOPROTEIN GENOTYPES IN BONE-MARROW TRANSPLANT RECIPIENTS", The Journal of infectious diseases, 169(4), 1994, pp. 769-774

Abstract

Using restriction analysis of polymerase chain reaction (PCR)-amplified DNA, the cytomegalovirus (CMV) envelope glycoprotein (gB and gH) genotypes were determined for virus isolates from 128 bone marrow transplant recipients with fatal or nonfatal CMV. All isolates could be assigned to one of four gB and gH genotypes previously identified by DNA sequencing studies. Isolates of gB type 1 were more commonly found to be of gH type 2, whereas gB types 2-4 were more commonly linked to gH type 1. A small frequency of recombination with gB was detected by restriction analysis of DNA from variable regions of the gp55 and gp116 domains. Multiple isolates from various sites of 29 patients were typed and, with three exceptions, the gB genotype remained constant in all isolates from a single patient. Patients who survived CMV infection more commonly shed virus of gB type 1 than those who died (P = .003). This significant difference of gB types among patient subsets is unexplained but raises the possibility that gB genotypes may serve as a markerfor pathogenicity of CMV strains in marrow transplant patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:12:09