Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
HIV-1 INFECTION OF IN-VITRO CULTURED HUMAN MONOCYTES - EARLY EVENTS AND INFLUENCE OF ANTI HIV-1 ANTIBODIES
Autore:
ARENDRUP M; OLOFSSON S; NIELSEN JO; HANSEN JES;
Indirizzi:
UNIV COPENHAGEN,HVIDOVRE HOSP,DEPT INFECT DIS 144 DK-2650 HVIDOVRE DENMARK UNIV COPENHAGEN,HVIDOVRE HOSP,DEPT INFECT DIS DK-2650 HVIDOVRE DENMARK UNIV GOTHENBURG,DEPT CLIN VIROL GOTHENBURG SWEDEN
Titolo Testata:
Archives of virology
fascicolo: 1-2, volume: 136, anno: 1994,
pagine: 35 - 52
SICI:
0304-8608(1994)136:1-2<35:HIOICH>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; NEUTRALIZING ANTIBODIES; MONONUCLEAR PHAGOCYTES; TYPE-1 INFECTION; MACROPHAGES; BINDING; BLOOD; CD4; STRAINS; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
M. Arendrup et al., "HIV-1 INFECTION OF IN-VITRO CULTURED HUMAN MONOCYTES - EARLY EVENTS AND INFLUENCE OF ANTI HIV-1 ANTIBODIES", Archives of virology, 136(1-2), 1994, pp. 35-52

Abstract

To characterize the role of the humoral immune response on HIV-1 infection of monocytes and macrophages (M phi s) we examined the susceptibility of in vitro cultured monocyte/M phi s to various HIV-1 isolates and the influence of heterologous and particularly autologous anti HIV-1 sera on this infection. Depending on the period of in vitro cultivation and the virus isolate used different patterns of susceptibility were detected. One week old monocyte/M phi s were highly susceptible toHIV-1 infection, in contrast to monocyte/M phi s cultured 4 weeks. The infection by virus isolated immediately after seroconversion lead topersistent infection with high level of antigen production in contrast to infection by homologous virus isolated later. MAb against the V3-IIIB loop and sCD4 inhibited the infection of monocyte/M phi s in a dose dependent manner, indicating that infection requires binding to CD4and that post binding events may be common to the infection of lymphocytes. Anti HIV-1 sera showed neutralizing activity against heterologous and even autologous escape virus. This finding, together with the observation that monocytes and M phi s are infected in vivo, suggests that protection against HIV-1 infection of monocytes and M phi s in vivo may not be obtainable by the humoral immune response alone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:16:44