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Titolo:
MOLECULAR-CLONING OF THE HUMAN HOMEOBOX GENE GOOSECOID (GSC) AND MAPPING OF THE GENE TO HUMAN-CHROMOSOME 14Q32.1
Autore:
BLUM M; DEROBERTIS EM; KOJIS T; HEINZMANN C; KLISAK I; GEISSERT D; SPARKES RS;
Indirizzi:
KERNFORSCHUNGSZENTRUM KARLSRUHE GMBH,INST GENET,POB 3640 D-76021 KARLSRUHE GERMANY UNIV CALIF LOS ANGELES,INST MOLEC BIOL LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,DEPT BIOL CHEM LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,SCH MED,DEPT MED LOS ANGELES CA 90024
Titolo Testata:
Genomics
fascicolo: 2, volume: 21, anno: 1994,
pagine: 388 - 393
SICI:
0888-7543(1994)21:2<388:MOTHHG>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSITU HYBRIDIZATION; DNA; MOUSE; EXPRESSION; ORGANIZER; LOCALIZATION; FRAGMENTS; SEQUENCES; EMBRYOS; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
M. Blum et al., "MOLECULAR-CLONING OF THE HUMAN HOMEOBOX GENE GOOSECOID (GSC) AND MAPPING OF THE GENE TO HUMAN-CHROMOSOME 14Q32.1", Genomics, 21(2), 1994, pp. 388-393

Abstract

Goosecoid is a homeobox gene first isolated from a Xenopus dorsal lipcDNA library. Homologous genes have been isolated from mouse, zebrafish, and chick. In all species examined, the gene is expressed and plays an important role during the process of gastrulation in early embryonic development. We report here the cloning of the human goosecoid gene (GSC) from a genomic library and the sequence of its encoded protein. The genomic organization and protein sequence of the human gene are highly conserved with respect to those of its Xenopus and mouse counterparts: all three genes consist of three exons, with conserved exon-intron boundaries; the sequence of the homeodomain is 100% conserved in most vertebrates. Using somatic cell hybrid and chromosomal in situ hybridization, the gene was mapped to chromosome 14q32.1. (C) 1994 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 10:41:18