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Titolo:
EFFECTS OF THE CCK RECEPTOR ANTAGONIST MK-329 ON FOOD-INTAKE IN BROILER-CHICKENS
Autore:
COVASA M; FORBES JM;
Indirizzi:
UNIV LEEDS,DEPT ANIM PHYSIOL & NUTR LEEDS LS2 9JT W YORKSHIRE ENGLAND
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 2, volume: 48, anno: 1994,
pagine: 479 - 486
SICI:
0091-3057(1994)48:2<479:EOTCRA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLECYSTOKININ OCTAPEPTIDE; ADMINISTERED CHOLECYSTOKININ; BEHAVIORAL ACTIONS; INDUCED SATIETY; RAT; L-364,718; PROGLUMIDE; PEPTIDES; VAGOTOMY; BRAIN;
Keywords:
CHOLECYSTOKININ; MK-329; CHICKENS; CONDITIONING; PREFERENCE TEST; SATIETY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
M. Covasa e J.M. Forbes, "EFFECTS OF THE CCK RECEPTOR ANTAGONIST MK-329 ON FOOD-INTAKE IN BROILER-CHICKENS", Pharmacology, biochemistry and behavior, 48(2), 1994, pp. 479-486

Abstract

The cholecystokinin (CCK) receptor antagonist MK-329 (previously L-364,718) was administered intraperitoneally to free-feeding broiler chickens and tested for conditioning effects using the colored food paradigm. The 8.0, 16.0, and 32.0 mu g/kg doses of MK-329 did not exert any effect on food intake and failed to condition a color preference or aversion. When higher doses were used (90, 180, and 360 mu g/kg) MK-329 caused a significant increase in food intake during the 2-h test period. Intravenously injected MK-329 (70, 140, and 280 mu g/kg) produced an increase in food intake, with maximum increases occurring at a dose of 70 mu g/kg. CCK (14 mu g/kg) caused a reduction in feeding, and this effect was not blocked by pretreatment with intraperitoneal injection of MK-329 (32, 90, 180, and 360 mu g/kg). The results question the role of endogenous CCK in satiety in chickens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:26:58