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Titolo:
DOPAMINE-RECEPTOR ANTAGONISTS BLOCK AMPHETAMINE AND PHENCYCLIDINE-INDUCED MOTOR STIMULATION IN RATS
Autore:
JACKSON DM; JOHANSSON C; LINDGREN LM; BENGTSSON A;
Indirizzi:
ASTRA ARCUS AB,CNS PRECLIN RES & DEV,DEPT BEHAV PHARMACOL S-15185 SODERTALJE SWEDEN
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 2, volume: 48, anno: 1994,
pagine: 465 - 471
SICI:
0091-3057(1994)48:2<465:DABAAP>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LOCOMOTOR-ACTIVITY; METHYL-D-ASPARTATE; NUCLEUS ACCUMBENS; BINDING-SITES; RELEASE; INVIVO; BRAIN; ACID; INVITRO; LESION;
Keywords:
DOPAMINE RECEPTORS; DOPAMINE D-1 RECEPTOR; DOPAMINE D-2 RECEPTOR; PHENCYCLIDINE; D-AMPHETAMINE; MOTOR ACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
D.M. Jackson et al., "DOPAMINE-RECEPTOR ANTAGONISTS BLOCK AMPHETAMINE AND PHENCYCLIDINE-INDUCED MOTOR STIMULATION IN RATS", Pharmacology, biochemistry and behavior, 48(2), 1994, pp. 465-471

Abstract

d-Amphetamine (DEX) and phencyclidine (PCP) increased motor activity in rats as measured in automated activity cages. Analysis of the stimulation indicated that both drugs increased horizontal activity (total activity), locomotion, and peripheral activity. However, DEX increasedwhile PCP decreased the incidence of rearing. The ability of different drugs to antagonise DEX- and PCP-induced increases in total activity(called stimulation) was measured. Dopamine (DA) D-1 receptor antagonists (SCH23390, NNC-01-0112) were 7-8 times more potent in blocking DEX than PCP. DA D-2 receptor antagonists (raclopride, remoxipride, haloperidol) were only 1-2 times more potent against DEX-induced stimulation. Nonselective DA receptor antagonists were also tested. Chlorpromazine was more potent against DEX than against PCP. Buspirone and sertindole were slightly more potent in blocking PCP than DEX. Ritanserin (5-HT2 receptor antagonist) was inactive against both stimulants. 8-OH-DPAT (5-HT1A receptor agonist) potentiated the stimulant effects of DEXand PCP. Prazosin (alpha(1)-adrenergic receptor antagonist) partiallyblocked both DEX and PCP. Most drugs tested depressed spontaneous motor activity. Remoxipride and sertindole, however, caused very little depression even at doses several times higher than those needed to block DEX or PCP. The data show clear pharmacological differences between DEX- and PCP-induced stimulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:48:42