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Titolo:
ANTIDEPRESSANT TREATMENT AND LIMBIC SEROTONERGIC MECHANISMS REGULATING RAT LOCOMOTOR-ACTIVITY
Autore:
PLAZNIK A; STEFANSKI R; PALEJKO W; BIDZINSKI A; KOSTOWSKI W; JESSA M; NAZAR M;
Indirizzi:
INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST,AL SOBIESKIEGO 1-9 PL-02957 WARSAW POLAND MED ACAD WARSAW,DEPT CLIN & EXPTL PHARMACOL WARSAW POLAND INST PSYCHIAT & NEUROL,DEPT BIOCHEM WARSAW POLAND
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 2, volume: 48, anno: 1994,
pagine: 315 - 325
SICI:
0091-3057(1994)48:2<315:ATALSM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-ACCUMBENS; ELECTROCONVULSIVE SHOCK; SHORT-TERM; BRAIN; DRUGS; HIPPOCAMPUS; 8-OH-DPAT; RECEPTORS; AGONISTS; LITHIUM;
Keywords:
8-OHDPAT; BUSPIRONE; DOI-HCL; ALPHA-METHYL-5-HT; RITANSERIN; CITALOPRAM; DESIPRAMINE; ECS; 5,7-DHT; NUCLEUS ACCUMBENS; MICROINJECTIONS; OPEN FIELD; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
A. Plaznik et al., "ANTIDEPRESSANT TREATMENT AND LIMBIC SEROTONERGIC MECHANISMS REGULATING RAT LOCOMOTOR-ACTIVITY", Pharmacology, biochemistry and behavior, 48(2), 1994, pp. 315-325

Abstract

The effects of chronic administration of desipramine, citalopram, andelectroconvulsive shocks (ECS) on changes in rat motility after intraaccumbens (NAS) injections of selective serotonergic drugs were studied in intact and 5.7-DHT lesioned animals. It was shown that local injections of 8-OHDPAT and DOI-HCl depressed rat locomotor activity. Theireffects appeared to be mediated postsynaptically, and could be antagonized by NAN-190 and ritanserin, respectively. Chronic but not acute pretreatment of rats with antidepressants (21 days long; the experimentwas performed 24 h after the last dose) as well as repeated ECS (shocks were applied five times every second day), antagonized behavioral depression after 8-OHDPAT and DOI-HCl. The influence of antidepressant treatment was prevented by serotonergic lesions. Chronic administration of antidepressants and ECS did not equivocally affect the levels or metabolism of 5-HT, dopamine, and noradrenaline in the rat limbic forebrain. It is concluded that the present data indicate diminished activity of 5-HT systems related to the 5-HT1A and 5-HT2 receptors in the limbic nucleus, after chronic antidepressant treatment. This effect of drugs and ECS concerns nervous processes linked with the function of postsynaptically localized 5-HT receptor subtypes, and it probably depends on intact presynaptic 5-HT innervation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:39:05