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Titolo:
INITIATION AND MAINTENANCE OF ORAL ETHANOL SELF-ADMINISTRATION IN FEMALE SPRAGUE-DAWLEY RATS
Autore:
NEILL JC; DOMENEY AM; COSTALL B;
Indirizzi:
UNIV BRADFORD,SCH PHARM BRADFORD BD7 1DP W YORKSHIRE ENGLAND
Titolo Testata:
Alcohol
fascicolo: 3, volume: 11, anno: 1994,
pagine: 207 - 218
SICI:
0741-8329(1994)11:3<207:IAMOOE>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALCOHOL-PREFERRING P; LOW-DOSE ETHANOL; REINFORCED BEHAVIOR; HOUSING CONDITIONS; FOOD-DEPRIVATION; DRINKING; ACQUISITION; PREFERENCE; SCHEDULE; STRAINS;
Keywords:
ALCOHOL; RAT; SELF-ADMINISTRATION; POSITIVE REINFORCEMENT; LIMITED ACCESS MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Neill et al., "INITIATION AND MAINTENANCE OF ORAL ETHANOL SELF-ADMINISTRATION IN FEMALE SPRAGUE-DAWLEY RATS", Alcohol, 11(3), 1994, pp. 207-218

Abstract

Group-housed female Sprague-Dawley rats were trained to self-administer 5% ethanol (v/v) in a large self-administration chamber (100 x 40 x40 cm) following three different initiation methods. The procedures were 1) an ethanol injection procedure, 2) a sucrose substitution procedure, and 3) a prandial drinking technique. Only the prandial drinkingmethod served to maintain responding for ethanol in the absence of water deprivation or sweetening of the alcohol solution. Rats trained using this technique showed a large preference for 5% ethanol over waterand a significant increase in locomotor activity while responding for5% ethanol but not while responding for water. When the concentrationof ethanol was increased from 1% to 32%, the amount of ethanol ingested increased up to a maximum of 1.233 +/- 0.3 g/kg of 32% ethanol, andresponse rates and number of ethanol deliveries followed an inverted U-shaped curve. Appreciable blood ethanol levels were detected immediately following self-administration of 8% ethanol. These results show that, in female Sprague-Dawley rats under the experimental conditions described, the prandial drinking technique was the most effective in inducing stable oral ethanol self-administration and suggest that under these conditions and in these subjects ethanol was acting as a positive reinforcer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:27:06