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Titolo:
PREFRONTAL AND TEMPORAL BLOOD-FLOW IN SCHIZOPHRENIA - RESTING AND ACTIVATION TECHNETIUM-99M-HMPAO SPECT PATTERNS IN YOUNG NEUROLEPTIC-NAIVEPATIENTS WITH ACUTE DISEASE
Autore:
CATAFAU AM; PARELLADA E; LOMENA FJ; BERNARDO M; PAVIA J; ROS D; SETOAIN J; GONZALEZMONCLUS E;
Indirizzi:
HOSP CLIN BARCELONA,DEPT NUCL MED,NUCL MED SERV,VILLARROEL 170 E-08036 BARCELONA SPAIN HOSP CLIN BARCELONA,DEPT PSYCHIAT BARCELONA SPAIN UNIV BARCELONA,FAC MED,BIOPHYS & BIOENGN LAB BARCELONA 7 SPAIN
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 6, volume: 35, anno: 1994,
pagine: 935 - 941
SICI:
0161-5505(1994)35:6<935:PATBIS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; GLUCOSE-METABOLISM; CINGULATE CORTEX; BRAIN-FUNCTION; HYPOFRONTALITY; DISORDER; ANXIETY;
Keywords:
HMPAO; SPECT; WISCONSIN CARD SORT TEST; SCHIZOPHRENIA; NEUROLEPTIC-NAIVE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Catafau et al., "PREFRONTAL AND TEMPORAL BLOOD-FLOW IN SCHIZOPHRENIA - RESTING AND ACTIVATION TECHNETIUM-99M-HMPAO SPECT PATTERNS IN YOUNG NEUROLEPTIC-NAIVEPATIENTS WITH ACUTE DISEASE", The Journal of nuclear medicine, 35(6), 1994, pp. 935-941

Abstract

This study assesses prefrontal and temporal regional cerebral blood flow (rCBF) changes in young, neuroleptic-naive schizophrenic patients with acute disease. Methods: A selected population of 10 young, never-treated schizophrenic women with acute disease was studied by two hexamethylpropyleneamine oxime (HMPAO) brain SPECT sessions, performed 48 hr apart, both at rest and during a prefrontal activation task using the Wisconsin Card Sort Test (WCST). All patients met Diagnostic and Statistical Manual of Mental Disorders, 3rd edition-revised criteria forschizophrenia or schizophreniform disorder, were neuroleptic-naive and had acute symptoms. Results: Under resting conditions, the schizophrenic group had significantly higher rCBF in the prefrontal regions, mainly in the left side and including the anterior cingulate, than did the controls. In addition, schizophrenic patients showed significant interhemispheric differences in prefrontal and posterior temporal index values at rest (left hyperfrontality and left hypotemporality). DuringWCST activation, the control group showed significant increases in prefrontal blood flow, whereas the schizophrenic group did not. Conclusion: These results support a physiologic dysfunction of the prefrontal cortex in schizophrenia that is present at the onset of the illness prior to neuroleptic treatment. Furthermore, both left hyperfrontality and left hypotemporality may indicate a brain lateralization defect in schizophrenia.

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Documento generato il 02/04/20 alle ore 02:34:49