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Titolo:
POLYMORPHISM OF THE TUMOR-NECROSIS-FACTOR GENES IN PATIENTS WITH DERMATITIS-HERPETIFORMIS
Autore:
MESSER G; KICK G; RANKI A; KOSKIMIES S; REUNALA T; MEURER M;
Indirizzi:
UNIV MUNICH,DEPT DERMATOL,FRAUENLOBSTR 9-11 D-80337 MUNICH GERMANY UNIV MUNICH,DEPT DERMATOL D-80337 MUNICH GERMANY HELSINKI UNIV HOSP,DEPT DERMATOL HELSINKI FINLAND FINNISH RED CROSS & BLOOD TRANSFUS SERV,CTR BLOOD TRANSFUS HELSINKI FINLAND
Titolo Testata:
Dermatology
, volume: 189, anno: 1994, supplemento:, 1
pagine: 135 - 137
SICI:
1018-8665(1994)189:<135:POTTGI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-ALPHA; TRANSGENIC MICE; BETA GENE; TNF LOCUS; LYMPHOTOXIN; COMPLEX;
Keywords:
DERMATITIS HERPETIFORMIS; HLA ASSOCIATION; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR BETA; GENE POLYMORPHISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
G. Messer et al., "POLYMORPHISM OF THE TUMOR-NECROSIS-FACTOR GENES IN PATIENTS WITH DERMATITIS-HERPETIFORMIS", Dermatology, 189, 1994, pp. 135-137

Abstract

In 18 patients with dermatitis herpetiformis (DH) of whom 16 were HLA-DR3 positive and 14 had the HLA-B8, -DR3 haplotype, the frequencies of known mutations of the tumor necrosis factor alpha (TNF-alpha) and TNF-beta genes were investigated using restriction fragment length polymorphism analysis and the single-strand conformational polymorphism technique. In DH, the phenotype frequency (28%) and allele frequency (0.58) of the rare TNF-beta allele TNFB1 were significantly increased (normal control 12.4% and 0.37). For the TNF-alpha promoter/enhancer polymorphism, the rare allele TNF2 was more frequent in DH patients (11%,0.47) compared to controls (2%, 0.16). Since functional studies have associated the rare TNFB1 and TNF2 alleles with a higher secretion ofTNF upon activation in vitro, the predominance of these two 'high-response' TNF alleles in DH patients may represent a genetic basis for the chronic inflammatory response in the skin and mucosal tissues of patients with DH.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 10:39:40