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Titolo:
A POSSIBLE CELL-BIOLOGIC MECHANISM INVOLVED IN BLISTER FORMATION OF BULLOUS PEMPHIGOID - ANTI-180-KD BPA ANTIBODY IS AN INITIATOR
Autore:
KITAJIMA Y; HIRAKO Y; OWARIBE K; YAOITA H;
Indirizzi:
GIFU UNIV,SCH MED,DEPT DERMATOL,40 TSUKASAMACHI GIFU 500 JAPAN NAGOYA UNIV,SCH SCI,DEPT MOLEC BIOL NAGOYA 46401 JAPAN JICHI MED SCH,DEPT DERMATOL MINAMI KAWACHI TOCHIGI JAPAN
Titolo Testata:
Dermatology
, volume: 189, anno: 1994, supplemento:, 1
pagine: 46 - 49
SICI:
1018-8665(1994)189:<46:APCMII>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN KINASE-C; STRUCTURAL-ANALYSIS; EPITHELIAL-CELLS; PLASMA-MEMBRANE; CARCINOMA-CELLS; ANTIGEN BPAG1; HEMIDESMOSOMES; KERATINOCYTES; TRANSLOCATION; COMPONENT;
Keywords:
BULLOUS PEMPHIGOID; HEMIDESMOSOME; AUTOIMMUNE DISEASE; KERATINOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
Y. Kitajima et al., "A POSSIBLE CELL-BIOLOGIC MECHANISM INVOLVED IN BLISTER FORMATION OF BULLOUS PEMPHIGOID - ANTI-180-KD BPA ANTIBODY IS AN INITIATOR", Dermatology, 189, 1994, pp. 46-49

Abstract

In this short review, we summarize the results of our recent studies on the effects of anti-bullous-pemphigoid antigen (BPA) antibodies andBP sera on the hemidesmosome in cultured keratinocytes (DJM-1 cells) as examined by immunofluorescence microscopy. The 180-kD and the 230-kD BPAs localized on the basal plasma membrane showed a homogeneously dotted pattern in cells grown with low Ca2+ (0.07 mM), while they formed a peculiar concentric ring or arch (ring/arch) pattern in cells grown with high Ca2+ (1.87 mM). In addition, the 180-kD BPA was distributed also on the lateral/apical cell membrane, and the 230-kD BPA was found in the cytoplasm. The high Ca2+ ring/arch arrangement of BPAs was formed within 3 h after the low-high Ca2+ switch. Anti-180-kD BPA monoclonal antibodies (MAbs) and BP sera, but not anti-230-kD BPA MAbs, which were added into this system, caused the internalization of the 180-kD BPA from the lateral/apical cell membrane and inhibited the formation of the ring/arch pattern. These results suggest that autoantibodiesto the 180-kD, but not to the 230-kD, BPAs may directly bind to the antigen on the cell surface of the basal cells and disturb the formation of hemidesmosomes. The 180-kD BPA appears to be an initiator of blister formation.

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Documento generato il 30/11/20 alle ore 15:54:33