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Titolo:
INHIBITORY-ACTION OF (-)-EPIGALLOCATECHIN GALLATE ON RADIATION-INDUCED MOUSE ONCOGENIC TRANSFORMATION
Autore:
KOMATSU K; TAUCHI H; YANO N; ENDO S; MATSUURA S; SHOJI S;
Indirizzi:
HIROSHIMA UNIV,RES INST RADIAT BIOL & MED,DEPT RADIAT BIOL,MINAMI KU HIROSHIMA 734 JAPAN HIROSHIMA UNIV,RES INST RADIAT BIOL & MED,DEPT GENETICOPATHOL,MINAMI KU HIROSHIMA 734 JAPAN
Titolo Testata:
Cancer letters
fascicolo: 2, volume: 112, anno: 1997,
pagine: 135 - 139
SICI:
0304-3835(1997)112:2<135:IO(GOR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-TRANSFORMATION; TUMOR PROMOTER; GREEN TEA; 12-O-TETRADECANOYLPHORBOL-13-ACETATE; CARCINOGENESIS; INVITRO; MICE;
Keywords:
GREEN TEA; EGCG; ANTICARCINOGENIC EFFECT; C3H10T1/2 CELLS; RADIATION-INDUCED TRANSFORMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
K. Komatsu et al., "INHIBITORY-ACTION OF (-)-EPIGALLOCATECHIN GALLATE ON RADIATION-INDUCED MOUSE ONCOGENIC TRANSFORMATION", Cancer letters, 112(2), 1997, pp. 135-139

Abstract

The anticarcinogenic activity of a major component of green tea, (-) epigallocatechin gallate (EGCg) was examined by using the radiation-induced oncogenic transformation in C3H10T1/2 cells. EGCg substantially suppressed the radiation-induced transformation so that the transformation frequency with 15 mu M of ECCg was reduced nearly to spontaneous levels. This effect of EGCg was in a dose-dependent manner and significant suppression of transformation was observed even in treatment of cells with 5 mu M of EGCg concentration where the cytotoxicity was mild, The inhibitory effect of EGCg was maximal when it was present duringthe entire incubation period. However, neither treatment Drier to norconcurrent with radiation was effective, suggesting that EGCg action is mainly involved in the promotional stage of C3H10T1/2 cell transformation. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 12:33:24