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Titolo:
HTLV-1 MESSENGER-RNA IS EXPRESSED IN-VIVO IN ADULT T-CELL LEUKEMIA LYMPHOMA PATIENTS - AN IN-SITU HYBRIDIZATION STUDY/
Autore:
SETOYAMA M; FUJIYOSHI T; MIZOGUCHI S; KATAHIRA Y; YASHIKI S; TARA M; KANZAKI T; SONODA S;
Indirizzi:
KAGOSHIMA UNIV,FAC MED,DEPT DERMATOL,8-35-1 KAGOSHIMA 890 JAPAN KAGOSHIMA UNIV,FAC MED,DEPT VIROL KAGOSHIMA 890 JAPAN KAGOSHIMA MUNICIPAL HOSP,DEPT INTERNAL MED KAGOSHIMA 890 JAPAN
Titolo Testata:
International journal of cancer
fascicolo: 5, volume: 57, anno: 1994,
pagine: 760 - 764
SICI:
0020-7136(1994)57:5<760:HMIEII>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD MONONUCLEAR-CELLS; I-ASSOCIATED MYELOPATHY; VIRUS TYPE-I; INSITU HYBRIDIZATION; LEUKEMIA-LYMPHOMA; FRESH; RETROVIRUS; INVITRO; LYMPHOCYTES; CARRIERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
M. Setoyama et al., "HTLV-1 MESSENGER-RNA IS EXPRESSED IN-VIVO IN ADULT T-CELL LEUKEMIA LYMPHOMA PATIENTS - AN IN-SITU HYBRIDIZATION STUDY/", International journal of cancer, 57(5), 1994, pp. 760-764

Abstract

Adult T-cell leukemia/lymphoma (ATLL) is a malignancy involving peripheral blood, lymph nodes, skin and other organs. Human T-cell leukemiavirus type I (HTLV-I) is etiologically associated with ATLL but cannot be detected by conventional methods in fresh samples of peripheral blood and skin taken from ATLL. The aim of this study was to investigate the feasibility of an in situ hybridization technique for detection of HTLV-I mRNA in atypical lymphoid cells of peripheral blood and skinlesions of patients with ATLL. We detected variable amounts of HTLV-Itax mRNA in the nuclei and cytoplasm of these cells in fresh peripheral blood samples and skin lesions from ATLL patients, and also in asymptomatic HTLV-I infected donors to a lesser extent. Out of 10 patientswith ATLL, 7 showed strong positive in situ hybridization whereas theother 3 were only weakly positive. However, in the last 3 cases, the reaction became strongly positive after cells had been cultured for 24hr. Furthermore, all 3 asymptomatic HTLV-I-infected donors exhibited a weakly positive response in their apparently mature lymphoid cells. (C) 1994 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 23:41:40