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Titolo:
USE OF SUPERPARAMAGNETIC CONTRAST-MEDIA TO SUPPRESS SIGNAL FROM FLOWING SPINS - PRELIMINARY EXPERIENCE
Autore:
DUERK JL; HURST GC;
Indirizzi:
METROHLTH MED CTR,DEPT RADIOL,2500 METROHLTH DR CLEVELAND OH 44109 METROHLTH MED CTR,DEPT BIOMED ENGN CLEVELAND OH 44109 METROHLTH MED CTR,DEPT CHEM CLEVELAND OH 44109 CASEWESTERN UNIV CLEVELAND OH 44109
Titolo Testata:
Journal of magnetic resonance imaging
fascicolo: 3, volume: 4, anno: 1994,
pagine: 413 - 417
SICI:
1053-1807(1994)4:3<413:UOSCTS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
IRON-OXIDE;
Keywords:
ARTIFACT; CONTRAST ENHANCEMENT; CONTRAST MEDIA, EXPERIMENTAL STUDIES; FLOW ARTIFACT; FLOW SUPPRESSION; HEART, FLOW DYNAMICS; HEART; IRON; VASCULAR STUDIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Duerk e G.C. Hurst, "USE OF SUPERPARAMAGNETIC CONTRAST-MEDIA TO SUPPRESS SIGNAL FROM FLOWING SPINS - PRELIMINARY EXPERIENCE", Journal of magnetic resonance imaging, 4(3), 1994, pp. 413-417

Abstract

The authors describe their preliminary experience with the use of superparamagnetic magnetic resonance (MR) imaging contrast media for suppression of signal from flowing blood. The goal of this work was to determine if a superparamagnetic contrast agent could successfully eliminate blood signal during cardiac-gated MR imaging, thereby eliminating or reducing flow artifacts associated with the complex and variable hemodynamics within the heart chambers. Imaging and data analysis were performed in 17 dogs subjected to experimental myocardial infarction aspart of a parallel project. Six doses (0.2, 1, 2, 3.5, 4, 5, and 10 mg/kg) of AMI-25, an experimental contrast agent, were used in the study. Spin-echo imaging was performed immediately before and every 5 minutes (for an average of 25 minutes) after bolus injection of the contrast agent. Variations in the image signal-to-noise ratio relative to a baseline (before injection of contrast agent) image were assessed as afunction of dose and time. Preliminary results suggest that a considerable reduction in blood flow artifacts and, hence, increases in imagesignal-to-noise ratio can be achieved at doses greater than or equal to 3.5 mg/kg, for approximately 20 minutes after injection. Doses equal to or less than 2 mg/kg and images obtained more than 20 minutes after injection (regardless of dose) did not reliably show hemodynamic artifact suppression.

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Documento generato il 01/10/20 alle ore 03:21:35