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Titolo:
RETROSPECTIVE ANALYSIS OF A SECONDARY STRUCTURE PREDICTION - THE CATALYTIC DOMAIN OF MATRIX METALLOPROTEINASES
Autore:
HODGKIN EE; GILLMAN IC; GILBERT RJ;
Indirizzi:
BRITISH BIOTECHNOL LTD,WATLINGTON RD OXFORD OX4 5LY ENGLAND
Titolo Testata:
Protein science
fascicolo: 6, volume: 3, anno: 1994,
pagine: 984 - 986
SICI:
0961-8368(1994)3:6<984:RAOASS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-STRUCTURE PREDICTION; ZINC-LIGATION; COLLAGENASES; THERMOLYSIN; ALIGNMENT; ASTACIN; FAMILY; NMR;
Keywords:
MATRIX METALLOPROTEINASE; PROTEIN FOLDING; SECONDARY STRUCTURE PREDICTION;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
E.E. Hodgkin et al., "RETROSPECTIVE ANALYSIS OF A SECONDARY STRUCTURE PREDICTION - THE CATALYTIC DOMAIN OF MATRIX METALLOPROTEINASES", Protein science, 3(6), 1994, pp. 984-986

Abstract

Secondary structure prediction of the catalytic domain of matrix metalloproteinases is evaluated in the light of recently published experimentally determined structures. The prediction was made by combining conformational propensity, surface probability, and residue conservationcalculated for an alignment of 19 sequences. The position of each observed secondary structure element was correctly predicted with a high degree of accuracy, with a single beta-strand falsely predicted. The domain fold was also anticipated from the prediction by analogy with the structural elements found in the distantly related metalloproteinases thermolysin, astacin, and adamalysin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:26:24