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Titolo:
CIGARETTE-SMOKING AND OTHER BEHAVIORAL RISK-FACTORS FOR RECURRENCE OFCOLORECTAL ADENOMATOUS POLYPS (NEW-YORK-CITY, NY, USA)
Autore:
JACOBSON JS; NEUGUT AI; MURRAY T; GARBOWSKI GC; FORDE KA; TREAT MR; WAYE JD; SANTOS J; AHSAN H;
Indirizzi:
COLUMBIA UNIV COLL PHYS & SURG,DIV ONCOL,630 W 168TH ST NEW YORK NY 10032 COLUMBIA UNIV COLL PHYS & SURG,DIV ONCOL,630 W 168TH ST NEW YORK NY 10032
Titolo Testata:
CCC. Cancer causes & control
fascicolo: 3, volume: 5, anno: 1994,
pagine: 215 - 220
SICI:
0957-5243(1994)5:3<215:CAOBRF>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Keywords:
ALCOHOL, COLORECTAL ADENOMATOUS POLYPS; POLYP RECURRENCE; SMOKING; UNITED-STATES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Jacobson et al., "CIGARETTE-SMOKING AND OTHER BEHAVIORAL RISK-FACTORS FOR RECURRENCE OFCOLORECTAL ADENOMATOUS POLYPS (NEW-YORK-CITY, NY, USA)", CCC. Cancer causes & control, 5(3), 1994, pp. 215-220

Abstract

Adenomatous polyps (hereinafter referred to as adenomas) are known precursors of colorectal cancer. Cigarette smoking has been associated with adenomas but not with colorectal cancer, while alcohol and fat intake have been associated with both adenomas and cancer in some studies. Approximately 30 percent of patients with resected adenomas develop another adenoma within three years. This case-control study explores the association of cigarette smoking with adenoma recurrence. Between April 1986 and March 1988, we administered a questionnaire to colonoscoped patients aged 35 to 84 years in three New York City (NY, USA) practices. We compared 186 recurrent polyp cases (130 males, 56 females) and 330 controls (187 males, 143 females) who had a history of polypectomy but normal follow-up colonoscopy, by cigarette-smoking pack-years adjusted for possible confounders. Risk for a metachronous or recurrent adenoma was significantly greater in the highest quartile of smokersthan in never-smokers among both men (odds ratio [OR] = 1.8, 95 percent confidence interval [CI] = 1.0-3.4) and women (OR = 3.6, CI = 1.7-7.6). Adjustment for time since smoking cessation reduced risk only slightly, as did adjustment for dietary fat intake, which itself remainedsignificant. No association was found between alcohol intake and riskof recurrence. Cigarette smokers appear to have an elevated risk of adenoma recurrence that is not eliminated entirely by smoking cessation. Intervention trials that use adenoma recurrence as an endpoint should take smoking into account.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 00:47:56