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Titolo:
A G-PROTEIN-BASED MODEL OF ADAPTATION IN DICTYOSTELIUM-DISCOIDEUM
Autore:
TANG YH; OTHMER HG;
Indirizzi:
UNIV UTAH,DEPT MATH SALT LAKE CITY UT 84112
Titolo Testata:
Mathematical biosciences
fascicolo: 1, volume: 120, anno: 1994,
pagine: 25 - 76
SICI:
0025-5564(1994)120:1<25:AGMOAI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAMP SIGNALING RESPONSE; CYCLIC 3',5'-AMP RELAY; BETA-ADRENERGIC RECEPTORS; ADENYLATE-CYCLASE; INOSITOL TRISPHOSPHATE; TRANSDUCTION PATHWAYS; AMP RELAY; OSCILLATIONS; ACTIVATION; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
CompuMath Citation Index
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
Y.H. Tang e H.G. Othmer, "A G-PROTEIN-BASED MODEL OF ADAPTATION IN DICTYOSTELIUM-DISCOIDEUM", Mathematical biosciences, 120(1), 1994, pp. 25-76

Abstract

A new model is proposed based on signal transduction via G proteins for adaptation of the signal relay process in the cellular slime mold Dictyostelium discoideum. The kinetic constants involved in the model are estimated from Dictyostelium discoideum and other systems. A qualitative analysis of the model shows how adaptation arises, and numericalcomputations show that the model agrees with observations in both perfusion and suspension experiments. Several experiments that can serve to test the model are suggested.

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Documento generato il 16/07/20 alle ore 05:58:21