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Titolo:
THE SUSCEPTIBILITY OF SPONTANEOUSLY DIABETIC MICE TO CADMIUM-METALLOTHIONEIN NEPHROTOXICITY
Autore:
JIN TY; NORDBERG GF; SEHLIN J; LEFFLER P; WU J;
Indirizzi:
UMEA UNIV,DEPT ENVIRONM MED S-90187 UMEA SWEDEN UMEA UNIV,DEPT HISTOL & CELL BIOL S-90187 UMEA SWEDEN
Titolo Testata:
Toxicology
fascicolo: 2, volume: 89, anno: 1994,
pagine: 81 - 90
SICI:
0300-483X(1994)89:2<81:TSOSDM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
KIDNEY; RAT; TOXICITY; MELLITUS;
Keywords:
OBESE-HYPERGLYCEMIC MICE; DIABETES; CADMIUM-METALLOTHIONEIN; PROTEINURIA; CALCIURIA; NEPHROTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
T.Y. Jin et al., "THE SUSCEPTIBILITY OF SPONTANEOUSLY DIABETIC MICE TO CADMIUM-METALLOTHIONEIN NEPHROTOXICITY", Toxicology, 89(2), 1994, pp. 81-90

Abstract

Cadmium metallothionein (CdMT) was injected subcutaneously into obesehyperglycaemic Umea ob/ob mice or their lean litter mates (normal mice) at doses of 0, 0.1 and 0.4 mg Cd/kg. Proteinuria and calciuria wereinduced in both types of mice, but in the ob/ob mice this condition developed at a lower dose of CdMT (0.1 mg Cd/kg) than in the normal mice (0.4 mg Cd/kg). These results show, therefore, that Umea ob/ob mice are particularly susceptible to CdMT-induced nephrotoxicity. The mechanism underlying this phenomenon needs to be further investigated. After the administration of CdMT, a dose-related increase in glycosuria was observed in both types of mice, in spite of decreased levels of serum insulin and glucose. It is suggested that such glycosuria induced byCdMT could be one of the signs of cadmium nephrotoxicity. The resultsof the present study thus indicate that metabolic changes like those in diabetes may increase susceptibility to cadmium-induced renal tubular damage.

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Documento generato il 30/11/20 alle ore 07:09:25