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Titolo:
AGE-RELATED-CHANGES IN THE DNA AND RNA-CONTENT OF THE BRAIN IN SPONTANEOUSLY HYPERTENSIVE RATS
Autore:
NAKANE H; NAKAHARA T; YAO H; OOBOSHI H; IBAYASHI S; UCHIMURA H; FUJISHIMA M;
Indirizzi:
KYUSHU UNIV,FAC MED,DEPT INTERNAL MED 2,HIGASHI KU,MAIDASHI 3-1-1 FUKUOKA 812 JAPAN KYUSHU UNIV,FAC SCI,DEPT CHEM FUKUOKA 812 JAPAN
Titolo Testata:
Neurochemical research
fascicolo: 3, volume: 22, anno: 1997,
pagine: 253 - 256
SICI:
0364-3190(1997)22:3<253:AITDAR>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; ELECTROCHEMICAL DETECTION; NEURONAL DEATH; ISCHEMIA; ADULT; METABOLISM; RELEASE; REGIONS;
Keywords:
AGING; DNA; RNA; BRAIN; SHR; HPLC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
H. Nakane et al., "AGE-RELATED-CHANGES IN THE DNA AND RNA-CONTENT OF THE BRAIN IN SPONTANEOUSLY HYPERTENSIVE RATS", Neurochemical research, 22(3), 1997, pp. 253-256

Abstract

To elucidate the effects of aging accompanied with hypertension on brain nucleic acid, we measured both the DNA and RNA contents of six specific brain regions in adult (5-6 months old) and aged (18-22 months old) female spontaneously hypertensive rats (SHRs). Although no statistical difference was observed in the RNA content, the DNA content did tend to increase in the hippocampal CAI of aged SHR (4.24 +/- 0.55 ng/mu g protein, mean +/- SD, n = 6) in comparison to that of adult SHR (3.21 +/- 0.71 ng/mu g protein, n = 4). Hence, aged SHRs showed a significant decrease in the RNA to DNA ratio in the CA1 subfield of the hippocampus (3.79 +/- 0.61) compared to adult SHR (5.27 +/- 0.81). On the other hand, no other regions, except for the dorsolateral region of the striatum, showed any difference in the RNA/DNA ratio between aged and adult SHR. We therefore conclude that subtle changes in the nucleic acid occur in vulnerable regions of the brain in aged SHRs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:05:25