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Titolo:
THE EFFECT OF DECREASED CATECHOLAMINE TRANSMISSION ON ERP INDEXES OF SELECTIVE ATTENTION
Autore:
SHELLEY AM; CATTS SV; WARD PB; ANDREWS S; MITCHELL P; MICHIE P; MCCONAGHY N;
Indirizzi:
YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PSYCHIAT,1300 MORRIS PK AVE BRONX NY 10461 UNIV NEW S WALES,SCH PSYCHOL KENSINGTON NSW 2033 AUSTRALIA UNIV NEW S WALES,SCH PSYCHIAT KENSINGTON NSW 2033 AUSTRALIA PRINCE WALES HOSP,DEPT PSYCHIAT,SCH BEHAV SCI SYDNEY NSW AUSTRALIA MACQUARIE UNIV N RYDE NSW AUSTRALIA
Titolo Testata:
Neuropsychopharmacology
fascicolo: 3, volume: 16, anno: 1997,
pagine: 202 - 210
SICI:
0893-133X(1997)16:3<202:TEODCT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; NORMAL ADULT HUMANS; MONOAMINE PATHWAYS; CLONIDINE; DOPAMINE; DISORDER; MODEL; METHYLPHENIDATE; SCHIZOPHRENIA; NORADRENALINE;
Keywords:
CATECHOLAMINES; CLONIDINE; DROPERIDOL; ERPS; SELECTIVE ATTENTION; PROCESSING NEGATIVITY; P3;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Shelley et al., "THE EFFECT OF DECREASED CATECHOLAMINE TRANSMISSION ON ERP INDEXES OF SELECTIVE ATTENTION", Neuropsychopharmacology, 16(3), 1997, pp. 202-210

Abstract

This study examines the effect of decreased catecholamine transmission on event-related potential (ERP) indices of selective attention. Intravenous clonidine (1.5 mu g/kg Catapres), droperidol (15 mu g/kg Droleptan), or placebo were administered to healthy adult males prior to performance of a multidimensional auditory selective attention task (SAT) in which dichotically presented sequences of tone pips varied on dimensions of location (left or right ear), pitch (high or low), and duration (short or long). Subjects were required to make a button press response to infrequent ''target'' stimuli that matched a prespecified stimulus on three dimensions. ERPs were recorded during the task. Clonidine led to a significant increase of processing negativity (PN) over 200-400 ms at the irrelevant location. Droperidol led to a significantincrease in reaction time (RT), a significant decrease in the hit rate, and an attenuation of PN over the 200- to 400-ms and 400- to 700-msepochs. Neither substance led to a significant change in P3 amplitude. The role of catecholamines in the selective attention subprocesses of ''tuning'' and ''switching'' is discussed. (C) 1997 American Collegeof Neuropsychopharmacology.

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Documento generato il 03/07/20 alle ore 14:51:02