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Titolo:
A DOPAMINERGIC NEUROTOXIN, THYL-6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE, N-METHYL(R)SALSOLINOL, AND ITS OXIDATION-PRODUCT, 1,2(N)-DIMETHYL-6,7-DIHYDROXYISOQUINOLINIUM ION, ACCUMULATE IN THE NIGROSTRIATAL SYSTEM OF THE HUMAN BRAIN
Autore:
MARUYAMA W; SOBUE G; MATSUBARA K; HASHIZUME Y; DOSTERT P; NAOI M;
Indirizzi:
NAGOYA INST TECHNOL,DEPT BIOSCI,SHOWA KU NAGOYA AICHI 466 JAPAN NAGOYA INST TECHNOL,DEPT BIOSCI,SHOWA KU NAGOYA AICHI 466 JAPAN NATL INST LONGEVITY SCI,BIOCHEM & METAB LAB,DEPT BASIC GERONTOL OBU JAPAN NAGOYA UNIV,SCH MED,DEPT NEUROL NAGOYA AICHI 466 JAPAN SHIMANE MED UNIV,DEPT LEGAL MED IZUMO SHIMANE 693 JAPAN AICHI MED UNIV,INST MED SCI AGING AICHI JAPAN PHARMACIA & UPJOHN INC MILAN ITALY
Titolo Testata:
Neuroscience letters
fascicolo: 1, volume: 223, anno: 1997,
pagine: 61 - 64
SICI:
0304-3940(1997)223:1<61:ADNT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALKALOIDS;
Keywords:
PARKINSONS DISEASE; AGING; N-METHYL(R)SALSOLINOL; 1,2-DIMETHYL-6,7-DIHYDROXYISOQUINOLINIUM ION; DOPAMINE; NIGRO-STRIATAL SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
W. Maruyama et al., "A DOPAMINERGIC NEUROTOXIN, THYL-6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE, N-METHYL(R)SALSOLINOL, AND ITS OXIDATION-PRODUCT, 1,2(N)-DIMETHYL-6,7-DIHYDROXYISOQUINOLINIUM ION, ACCUMULATE IN THE NIGROSTRIATAL SYSTEM OF THE HUMAN BRAIN", Neuroscience letters, 223(1), 1997, pp. 61-64

Abstract

N-Methyl(R)salsolinol was found to be an endogenous dopaminergic neurotoxin inducing parkinsonism in rodents and to increase in the cerebrospinal fluid of parkinsonian patients. The amounts of N-methyl(R)salsolinol and related compounds in the human brain regions were quantitatively analyzed. Only the (R)-enantiomer of salsolinol derivatives were detected, which suggests their enzymatic synthesis in situ. In the nigro-striatal system, the concentration of N-methyl(R)salsolinol was higher than in the frontal cortex, and its oxidized catechol isoquinolinium ion was detected only in the substantia nigra significantly. The accumulation of these neurotoxins in the nigro-striatal region might account for selective cell death of dopamine neurons in the substantia nigra of Parkinson's disease. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 04:40:40