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Titolo:
METHYLENE-BLUE REVERSES ENDOTOXIN-INDUCED HYPOTENSION
Autore:
KEANEY JF; PUYANA JC; FRANCIS S; LOSCALZO JF; STAMLER JS; LOSCALZO J;
Indirizzi:
BOSTON UNIV,MED CTR,DEPT MED,WHITAKER CARDIOVASC INST,CARDIOL SECT,W507,700 ALBANY ST BOSTON MA 02118 BRIGHAM & WOMENS HOSP,DEPT MED BOSTON MA 02115 VET ADM MED CTR W ROXBURY BOSTON MA 00000 UNIV MASSACHUSETTS,MED CTR,DEPT SURG WORCESTER MA 00000
Titolo Testata:
Circulation research
fascicolo: 6, volume: 74, anno: 1994,
pagine: 1121 - 1125
SICI:
0009-7330(1994)74:6<1121:MREH>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; VASCULAR SMOOTH-MUSCLE; CYCLIC-GMP ACCUMULATION; L-ARGININE; ENDOTHELIAL-CELLS; GUANYLATE CYCLASE; SUPEROXIDE ANION; TISSUE PREPARATIONS; RELAXING FACTOR; INHIBITION;
Keywords:
NITRIC OXIDE; LIPOPOLYSACCHARIDE; CGMP; S-NITROSOTHIOLS; METHYLENE BLUE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Keaney et al., "METHYLENE-BLUE REVERSES ENDOTOXIN-INDUCED HYPOTENSION", Circulation research, 74(6), 1994, pp. 1121-1125

Abstract

Hypotension in septic shock is a reflection of unregulated nitric oxide (NO) production and vascular smooth muscle guanylyl cyclase activation. We examined the effect of methylene blue on lipopolysaccharide (LPS)-induced shock in anesthetized rabbits. Shock was induced with 150 mu g/kg LPS after measurement of mean arterial pressure, platelet cGMP, and total plasma NO (nitrogen monoxide+S-nitrosothiol) content. Measurements were repeated before and after the intravenous administrationof 1, 5, and 10 mg/kg methylene blue in response to a 55% reduction in mean arterial pressure. At baseline, mean+/-SEM arterial pressure was 88+/-3 mm Hg, which fell to 51+/-3 mm Hg after LPS (P<.05). Methylene blue at doses of 1, 5, and 10 mg/kg produced a prompt dose-dependentincrease in mean arterial pressure to 69+/2, 77+/-3, and 81+/-2 mm Hg, respectively (P<.05 versus mean arterial pressure after LPS) in association with normalization of plasma total NO content (P<.05); however, methylene blue did not significantly affect intraplatelet cGMP levels. Thus, methylene blue restores normal arterial pressure in rabbits with septic shock. This effect is associated with persistent elevation of intraplatelet cGMP levels and normalization of total plasma NO content. These data are consistent with methylene blue-mediated inhibitionof NO synthase and/or degradation of NO in this model and suggest a novel therapeutic approach to the treatment of septic shock.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:51:00