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Titolo:
PROTECTIVE ROLE OF SYNTHETIC SIALYLATED OLIGOSACCHARIDE IN SEPSIS-INDUCED ACUTE LUNG INJURY
Autore:
RIDINGS PC; HOLLOWAY S; BLOOMFIELD GL; PHILLIPS ML; FISHER BJ; BLOCHER CR; SUGERMAN HJ; FOWLER AA;
Indirizzi:
DIV PULM & CRIT CARE MED,BOX 980050,MCV STN RICHMOND VA 23298 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT SURG RICHMOND VA 23298 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PEDIAT RICHMOND VA 23298 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT INTERNAL MED RICHMOND VA 23298 CYTEL CORP SAN DIEGO CA 92121
Titolo Testata:
Journal of applied physiology
fascicolo: 2, volume: 82, anno: 1997,
pagine: 644 - 651
SICI:
8750-7587(1997)82:2<644:PROSSO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; GRAM-NEGATIVE SEPSIS; LEUKOCYTE ADHESION MOLECULE-1; L-SELECTIN; MONOCLONAL-ANTIBODY; NEUTROPHIL ADHESION; CARBOHYDRATE LIGAND; CELL-ADHESION; ELAM-1; IDENTIFICATION;
Keywords:
ADULT RESPIRATORY DISTRESS SYNDROME; SEPTIC SHOCK; CELLULAR ADHESION MOLECULES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
P.C. Ridings et al., "PROTECTIVE ROLE OF SYNTHETIC SIALYLATED OLIGOSACCHARIDE IN SEPSIS-INDUCED ACUTE LUNG INJURY", Journal of applied physiology, 82(2), 1997, pp. 644-651

Abstract

Proper engagement of leukocyte and endothelial cell selectins with their counterreceptors is an initial step in neutrophil trafficking to sites of inflammation. Certain fucosylated carbohydrate determinants such as sialyl Lewis-x are proposed to act as these counterreceptors. Westudied the effects of a synthetic sialyl Lewis-x analog, CY-1503, onthe course of hemodynamic derangements and acute lung injury during experimental gram-negative sepsis. Anesthetized ventilated swine were made septic with an infusion of live Pseudomonas aeruginosa. A treatment group received an initial bolus of CY-1503 (60 mg/kg) before sepsis,followed by continuous infusion of CY-1503 (12 mg . kg(-1). h(-1)). Treatment with CY-1503 did not prevent the development of pulmonary hypertension, systemic hypotension, decline in cardiac output, or severe neutropenia. However, CY-1503 significantly attenuated lung injury, demonstrated by decreased bronchoalveolar lavage protein content and neutrophil influx, lowered lung myeloperoxidase activity, and improved arterial oxygenation. Neutrophils from septic and CY-1503 animals showedsignificant activation, reflected by upregulated CD18 expression and priming for oxidant burst compared with control animals. This study suggests blockade of selectin interactions as a potential therapeutic intervention in sepsis-induced lung injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 11:37:18