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Titolo:
PROLONGATION IN EXPIRATION EVOKED FROM VENTROLATERAL PENS OF ADULT-RATS
Autore:
JODKOWSKI JS; COLES SK; DICK TE;
Indirizzi:
CASE WESTERN RESERVE UNIV,UNIV HOSP CLEVELAND,DEPT MED,DIV PULM & CRIT CARE MED,11100 EUCLID AVE CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT NEUROSCI CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT PHYSIOL & BIOPHYS CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT MED CLEVELAND OH 44106
Titolo Testata:
Journal of applied physiology
fascicolo: 2, volume: 82, anno: 1997,
pagine: 377 - 381
SICI:
8750-7587(1997)82:2<377:PIEEFV>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY RHYTHM GENERATOR; PNEUMOTAXIC CENTER; ELECTRICAL-STIMULATION; PROJECTIONS; RESPONSES; NEURONS; CAT; MODULATION; NUCLEUS; INVITRO;
Keywords:
CONTROL OF RESPIRATION; A5 AREA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Jodkowski et al., "PROLONGATION IN EXPIRATION EVOKED FROM VENTROLATERAL PENS OF ADULT-RATS", Journal of applied physiology, 82(2), 1997, pp. 377-381

Abstract

Activation of neurons in the ventrolateral (vl) pens was hypothesizedto alter the breathing pattern because previous studies demonstrated apneusis after inhibiting neuronal activity with bilateral muscimol (10 mM) microinjections into the vl pens (17). The excitatory amino acidL-glutamate (10 mM) was microinjected (10-100 nl) into the vl pens inanesthetized, vagotomized, paralyzed, and ventilated adult rats (n=8). In four of these animals, the target site was approached from the ventral surface of the pens to avoid penetrating the dorsolateral (dl) pens. The expiratory phase was prolonged transiently and concurrently with the microinjection. The location of the injection sites included the A5 area, was independent of the approach, and was distinct from thedl pens. These results complement our previous data and indicate thatneurons located in the vl pens influence respiration specifically by prolonging expiration when activated and by delaying the inspiratory-to-expiratory phase transition when inhibited.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 01:22:49