Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ROLE OF GABA(A) RECEPTORS IN THE ACTIONS OF ALCOHOL AND IN ALCOHOLISM- RECENT ADVANCES
Autore:
KORPI ER;
Indirizzi:
ALKO LTD,BIOMED RES CTR,POB 350 SF-00101 HELSINKI FINLAND
Titolo Testata:
Alcohol and alcoholism
fascicolo: 2, volume: 29, anno: 1994,
pagine: 115 - 129
SICI:
0735-0414(1994)29:2<115:ROGRIT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; SUBUNIT MESSENGER-RNAS; BENZODIAZEPINE INVERSE AGONISTS; INDUCED MOTOR IMPAIRMENT; SHORT-SLEEP MICE; RAT-BRAIN SYNAPTONEUROSOMES; CEREBELLAR PURKINJE NEURONS; OPERATED CHLORIDE CHANNELS; SELECTIVELY-BRED MICE; SPINAL-CORD NEURONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
165
Recensione:
Indirizzi per estratti:
Citazione:
E.R. Korpi, "ROLE OF GABA(A) RECEPTORS IN THE ACTIONS OF ALCOHOL AND IN ALCOHOLISM- RECENT ADVANCES", Alcohol and alcoholism, 29(2), 1994, pp. 115-129

Abstract

Brain GABAergic mechanisms are interesting with regard to their role in the actions of ethanol. The present review summarizes some of the more recent studies, most of them biochemical, electrophysiological andpharmacogenetic. While there is still a number of controversies, e.g.regarding the molecular mechanisms of ethanol enhancement of GABA(A) receptor-mediated anion flux and the effects of chronic alcohol administration on the receptors in experimental animals and man, there is a substantial body of evidence supporting the involvement of these mechanisms in many behavioural actions of ethanol. Two recent findings warrant further molecular biological studies on die interaction between ethanol and the GABA(A) receptor, and the extension of the studies to human alcoholics: first, the effects of ethanol on the GABA(A) receptor are dependent on a specific gamma2 subunit with an additional phosphorylation site; second, genetically enhanced sensitivity to the motor-impairing effect of moderate ethanol doses has a likely biological basisin a single-nucleotide mutation in a cerebellum-specific GABA(A) receptor subunit. Further studies are also needed to establish the role ofGABAergic mechanisms in alcohol misuse and addiction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:25:57