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Titolo:
SENSITIZATION TO EARLY-LIFE STRESS AND RESPONSE TO CHEMICAL ODORS IN OLDER ADULTS
Autore:
BELL IR; SCHWARTZ GE; AMEND D; PETERSON JM; STINI WA;
Indirizzi:
TUCSON VET AFFAIRS MED CTR,DEPT PSYCHIAT,3601 S 6TH AVE,MS 11NH TUCSON AZ 85723 UNIV ARIZONA,DEPT PSYCHIAT TUCSON AZ 00000 UNIV ARIZONA,DEPT PSYCHOL TUCSON AZ 85721 UNIV ARIZONA,DEPT NEUROL TUCSON AZ 00000 UNIV ARIZONA,DEPT ANTHROPOL TUCSON AZ 85721
Titolo Testata:
Biological psychiatry
fascicolo: 11, volume: 35, anno: 1994,
pagine: 857 - 863
SICI:
0006-3223(1994)35:11<857:STESAR>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORGANIC-SOLVENT EXPOSURE; TIME-DEPENDENT SENSITIZATION; SELF-REPORTED ILLNESS; BEHAVIORAL SENSITIZATION; DOPAMINE RELEASE; BETA-ENDORPHIN; YOUNG-ADULTS; AMPHETAMINE; HALOPERIDOL; DISORDER;
Keywords:
CHEMICAL SENSITIVITY; CACOSMIA; TIME-DEPENDENT SENSITIZATION; STRESS; SHYNESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
I.R. Bell et al., "SENSITIZATION TO EARLY-LIFE STRESS AND RESPONSE TO CHEMICAL ODORS IN OLDER ADULTS", Biological psychiatry, 35(11), 1994, pp. 857-863

Abstract

This study examined the hypothesis that older persons who currently report illness from environmental chemical odors (cacosmia) may have experienced higher levels of stress early in life than did noncacosmic controls. The hypothesis derives from a time-dependent sensitization (TDS) model for cacosmia (Bell et al 1992) that predicts a relative interchangeability of stress and chemicals in inducing and eliciting sensitized responses in vulnerable individuals. Subjects were selected fromthose in the top 24% (cacosmic) and bottom 27% (noncacosmic) of a sample of 192 older adults (mean age 73.8 years) for self-reported frequency of illness from the odors of pesticide, car exhaust, paint, perfume, and new carpet. As in previous investigations, cacosmics were younger, more depressed, and more shy; cacosmics also included a higher proportion of women (83% versus 61%). As predicted, cacosmics rated themselves higher in stress for the first four decades of their lives, but not the recent past or present, even after controlling for depression,anxiety, hostility, shyness, age, and gender. Cacosmics reported increased prevalence of physician-diagnosed nasal allergies, breast cysts,hypothyroidism, sinusitis, food sensitivities, irritable bowel, and migraine headache. Only 4% of the overall sample (including 9% of the cacosmics) acknowledged the controversial physician diagnosis of ''chemical sensitivity. '' The replicated observation of greater shyness in cacosmics is consistent with the ability of hyperreactivity to novelty to predict enhanced susceptibility to TDS from low levels of pharmacological agents in animals. The findings support a TDS model for cacosmia and suggest that cacosmia as a symptom identifies a large subset of the nonindustrial population with significant psychophysiological health problems that merit further objective examination.

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Documento generato il 27/01/21 alle ore 01:35:08