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Titolo:
PRESSURE, VOLUME, AND CHEMOSENSITIVITY IN AFFERENT INNERVATION OF URINARY-BLADDER IN RATS
Autore:
MOSS NG; HARRINGTON WW; TUCKER MS;
Indirizzi:
UNIV N CAROLINA,DEPT PHYSIOL,CB 7545 CHAPEL HILL NC 27599
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 2, volume: 41, anno: 1997,
pagine: 695 - 703
SICI:
0363-6119(1997)41:2<695:PVACIA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELINATED PRIMARY AFFERENTS; INTERSTITIAL CYSTITIS; HYPOGASTRIC NERVE; FIBERS; CAT; POTASSIUM;
Keywords:
VISCERAL AFFERENTS; MECHANORECEPTORS; CHEMORECEPTORS; CYSTITIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
N.G. Moss et al., "PRESSURE, VOLUME, AND CHEMOSENSITIVITY IN AFFERENT INNERVATION OF URINARY-BLADDER IN RATS", American journal of physiology. Regulatory, integrative and comparative physiology, 41(2), 1997, pp. 695-703

Abstract

Bladder afferent nerve activity was recorded from the pelvic and hypogastric nerves of rats anesthetized with pentobarbital sodium. Bladderfilling with isotonic NaCl at a rate of 250 mu l/min excited multiunit afferent activity in the hypogastric nerve by 190 +/- 38% over background at a pressure of 30 mmHg, whereas 150 meq/l KCI at the same filling rate excited hypogastric nerve activity by 498 +/- 103% (P < 0.0001). This difference was localized to a group of chemosensitive fibers that are excited by bladder filling with KCl in a concentration-dependent fashion but are insensitive to bladder filling with NaCl. Bladder filling with 200 meq/l KCl at different filling rates caused a bursting pattern of discharge in these fibers at consistent bladder volumes but with a pressure threshold that increased proportionately with filling rate. Other hypogastric bladder afferent fibers were activated to asimilar extent by NaCl and KCl solutions. Chemoreceptive bladder afferent fibers were rare in the pelvic nerve (1 of 15 units), and multiunit preparations showed comparable excitations during bladder filling with NaCl and KCl solutions. The bursting activation of bladder chemoreceptive afferent nerves in hypogastric nerves could signal noxious overdistension and/or inflammation of the bladder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:04:09