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Titolo:
ROLE OF ADRENOCEPTORS IN THE HYPERTENSIVE RESPONSE TO FEEDING IN THE CONSCIOUS CALF
Autore:
BOWMAN ECJ; RODERICK GP; BLOOM SR; EDWARDS AV;
Indirizzi:
UNIV CAMBRIDGE,PHYSIOL LAB,DOWNING ST CAMBRIDGE CB2 3EG ENGLAND UNIV CAMBRIDGE,PHYSIOL LAB CAMBRIDGE CB2 3EG ENGLAND HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT MED LONDON W12 9DS ENGLAND
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 2, volume: 41, anno: 1997,
pagine: 607 - 614
SICI:
0363-6119(1997)41:2<607:ROAITH>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROPEPTIDE-Y; ANGIOTENSIN-II; CARDIOVASCULAR-RESPONSES; SPLANCHNIC NERVE; BLOOD-PRESSURE; RADIOIMMUNOASSAY; STIMULATION; INCREASES; BLOCKADE; HEART;
Keywords:
NEUROPEPTIDES; SYMPATHETIC SYSTEM; ADRENOCEPTOR BLOCKADE; HYPERTENSION; CATECHOLAMINES; NEUROPEPTIDE Y; SPLANCHNIC NERVE STIMULATION; ANGIOTENSIN II;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
E.C.J. Bowman et al., "ROLE OF ADRENOCEPTORS IN THE HYPERTENSIVE RESPONSE TO FEEDING IN THE CONSCIOUS CALF", American journal of physiology. Regulatory, integrative and comparative physiology, 41(2), 1997, pp. 607-614

Abstract

Ingestion of milk during suckling causes hypertension and tachycardiain young, unweaned animals of many species, but these responses are most pronounced in the calf. The present study was undertaken to assessthe extent to which this phenomenon depends on activation of adrenoceptors in these animals. Mean basal heart rate was 100 +/- 8 beats/min and mean basal aortic blood pressure was 92 +/- 5 mmHg. The rise in heart rate during feeding was almost completely suppressed after propranolol (2-4 mg/kg iv), which also significantly reduced the rise in blood pressure from 67 +/- 4 to 44 +/- 3 mmHg (P < 0.005). Additional pretreatment with phentolamine (1.0 mg/kg and less than or equal to 0.1 mg. min(-1). kg(-1) iv) virtually eliminated the rise in blood pressureduring feeding; it rose by only 8 +/- 4 mmHg (P < 0.001). Section of both splanchnic nerves also significantly reduced the rise in blood pressure during feeding, especially after pretreatment with propranolol. Neither section of the splanchnic nerves nor the administration of the blocking agents significantly affected the rises in plasma insulin and pancreatic polypeptide that occurred after feeding. There was no detectable rise in plasma neuropeptide Y concentration in response to feeding. The hypertensive response to direct electrical stimulation of the peripheral end of a splanchnic nerve and to intra-arterial injections of norepinephrine were completely abolished after combined pretreatment with atropine, propranolol, and phentolamine after the ipsilateral adrenal vein had been tied off. It is concluded that the cardiovascular changes that occur during feeding in these animals are attributable very largely, if not entirely, to activation of adrenoceptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 13:34:50