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Titolo:
INFLUENCE OF SIMULATED MICROGRAVITY ON THE SYMPATHETIC RESPONSE TO EXERCISE
Autore:
WOODMAN CR; KREGEL KC; TIPTON CM;
Indirizzi:
UNIV MISSOURI,DEPT VET BIOMED SCI,1600 E ROLLINS COLUMBIA MO 65211 UNIV ARIZONA,DEPT PHYSIOL TUCSON AZ 85721 UNIV IOWA,DEPT EXERCISE SCI IOWA CITY IA 52242
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 2, volume: 41, anno: 1997,
pagine: 570 - 575
SICI:
0363-6119(1997)41:2<570:IOSMOT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL NOREPINEPHRINE TURNOVER; HINDLIMB SUSPENSION; CHEMICAL SYMPATHECTOMY; RATS; WEIGHTLESSNESS; MUSCLE; VO2MAX;
Keywords:
HEAD-DOWN SUSPENSION; WEIGHTLESSNESS; CARDIOVASCULAR DECONDITIONING; ALPHA-METHYL-PARA-TYROSINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
C.R. Woodman et al., "INFLUENCE OF SIMULATED MICROGRAVITY ON THE SYMPATHETIC RESPONSE TO EXERCISE", American journal of physiology. Regulatory, integrative and comparative physiology, 41(2), 1997, pp. 570-575

Abstract

Rats exposed to simulated conditions of microgravity exhibit reductions in aerobic exercise capacity that may be due to an impaired abilityof the sympathetic nervous system (SNS) to mediate an increase in cardiac output and to redistribute blood flow. The purpose of this study was to quantify the sympathetic response to exercise in rats after exposure to 14 days of simulated microgravity or control conditions. To achieve this aim, rats were exposed to 14 days of head-down suspension (HDS) or cage control (CC) conditions. On day 14, norepinephrine (NE) synthesis was blocked with alpha-methyl-p-tyrosine, and the rate of NEdepletion after synthesis blockade was used to estimate SNS activity in the left ventricle, spleen, and soleus muscle during treadmill exercise at 75% of maximal oxygen uptake. When compared with CC rats, the sympathetic response to exercise in HDS rats was characterized by a lower rate of NE depletion in the left ventricle (-82%) and spleen (-42%). The rate of NE depletion in the soleus muscle was 47% higher. Thesedifferences could contribute to the decrement in aerobic capacity of HDS rats by impairing their ability to augment cardiac output and to redirect blood flow to actively contracting skeletal muscle during exercise.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:09:00