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Titolo:
DECREASED E-CADHERIN EXPRESSION IN ENDOMETRIAL CARCINOMA IS ASSOCIATED WITH TUMOR DEDIFFERENTIATION AND DEEP MYOMETRIAL INVASION
Autore:
SAKURAGI N; NISHIYA M; IKEDA K; OHKOUCH T; FURTH EE; HAREYAMA H; SATOH C; FUJIMOTO S;
Indirizzi:
HOKKAIDO UNIV,SCH MED,DEPT OBSTET & GYNECOL SAPPORO HOKKAIDO 060 JAPAN UNIV PENN,DEPT OBSTET & GYNECOL PHILADELPHIA PA 19104 UNIV PENN,DEPT PATHOL PHILADELPHIA PA 19104 UNIV PENN,DEPT LAB MED PHILADELPHIA PA 19104
Titolo Testata:
Gynecologic oncology
fascicolo: 2, volume: 53, anno: 1994,
pagine: 183 - 189
SICI:
0090-8258(1994)53:2<183:DEEIEC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CELL-ADHESION; EPITHELIAL-CELLS; SCATTER FACTOR; MOLECULE; CANCER; PATTERNS; INVASIVENESS; METASTASIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
N. Sakuragi et al., "DECREASED E-CADHERIN EXPRESSION IN ENDOMETRIAL CARCINOMA IS ASSOCIATED WITH TUMOR DEDIFFERENTIATION AND DEEP MYOMETRIAL INVASION", Gynecologic oncology, 53(2), 1994, pp. 183-189

Abstract

Decreased E-cadherin expression in tumor cells has been suggested to promote tumor invasiveness. We examined E-cadherin expression in 30 cases of endometrial carcinoma by immunohistochemistry using a monoclonal antibody to E-cadherin and investigated its correlation with other histopathologic features of the tumor. We observed that: (1) E-cadherinexpression decreased with toss of differentiation (P < 0.05); (2) E-cadherin expression was inversely correlated with depth of myometrial invasion (P < 0.05); (3) decreased E-cadherin expression was correlatedwith paraaortic node metastasis (P < 0.01); and (4) multivariate analysis comparing the depth of myometrial invasion to the pattern of E-cadherin expression, histologic grade, nuclear grade, and lymph-vascularspace invasion showed that the depth of myometrial invasion was most strongly correlated with decreased E-cadherin expression (P < 0.005). These findings seem to be consistent with the concept that the dissociation of cancer cells due to decreased expression of E-cadherin facilitates invasion of tumor celts. (C) 1994 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 01:16:38