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Titolo:
A PHASE-I TRIAL OF INTRAVENOUS INTERLEUKIN-6 IN PATIENTS WITH ADVANCED CANCER
Autore:
WEBER J; GUNN H; YANG J; PARKINSON D; TOPALIAN S; SCHWARTZENTRUBER D; ETTINGHAUSEN S; LEVITT D; ROSENBERG SA;
Indirizzi:
NCI,SURG BRANCH,BLDG 10,ROOM 2B42 BETHESDA MD 20892 SANDOZ INC,PHARMACEUT,CYTOKINE DEV UNIT E HANOVER NJ 00000
Titolo Testata:
Journal of immunotherapy with emphasis on tumor immunology
fascicolo: 4, volume: 15, anno: 1994,
pagine: 292 - 302
SICI:
1067-5582(1994)15:4<292:APTOII>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN RECOMBINANT INTERLEUKIN-6; STIMULATORY FACTOR-II; LYMPHOCYTES-T; GROWTH-FACTOR; CELL-LINES; MYELOID-LEUKEMIA; POTENT INDUCER; MICE; DIFFERENTIATION; IL-6;
Keywords:
PHASE I TRIAL; IL-6; ADVANCED CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
J. Weber et al., "A PHASE-I TRIAL OF INTRAVENOUS INTERLEUKIN-6 IN PATIENTS WITH ADVANCED CANCER", Journal of immunotherapy with emphasis on tumor immunology, 15(4), 1994, pp. 292-302

Abstract

Eighteen patients were treated with escalating doses of recombinant, Escherchia coli-derived human interleukin-6 (IL-6) intravenously every8 h. Therapy was given for two cycles of 7 days each separated by a week off therapy. Fevers and chills were observed in most patients. Mild renal and liver function abnormalities were noted at higher doses ofIL-6. Dose-limiting toxicity was reached at 30 mu g/kg i.v. every 8 hdue to reversible neurotoxicity, but significant rapidly reversible anemia and hyperglycemia were seen at lower doses. Platelet counts, white brood cell counts, and acute phase reactant levels were substantially elevated. No antitumor responses were seen. A maximum tolerated dose of 10 mu g/kg i.v. every 8 h for two 7-day cycles is recommended forfuture phase II trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 12:46:18