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Titolo:
EFFECTS DF CHOLECYSTOKININ TETRAPEPTIDE AND SULFATED CHOLECYSTOKININ-OCTAPEPTIDE IN RAT MODELS OF ANXIETY
Autore:
REX A; BARTH T; VOIGT JP; DOMENEY AM; FINK H;
Indirizzi:
HUMBOLDT UNIV BERLIN,MED FAC CHARITE,INST PHARMACOL & TOXICOL D-10098BERLIN GERMANY BATTELLE CTR RECH GENEVE,DIV HLTH CH-1227 CAROUGE SWITZERLAND
Titolo Testata:
Neuroscience letters
fascicolo: 1-2, volume: 172, anno: 1994,
pagine: 139 - 142
SICI:
0304-3940(1994)172:1-2<139:EDCTAS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED PLUS-MAZE; B-RECEPTOR; ANIMAL-MODEL; BRAIN; CCK; ANTAGONISTS; VALIDATION; VOCALIZATION; EXPLORATION; AGONISTS;
Keywords:
ANXIETY; CCK-4; CCK-8S; ANIMAL MODEL OF ANXIETY; ELEVATED PLUS MAZE; BLACK-AND-WHITE BOX; CONFLICT TEST; ULTRASOUND VOCALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
A. Rex et al., "EFFECTS DF CHOLECYSTOKININ TETRAPEPTIDE AND SULFATED CHOLECYSTOKININ-OCTAPEPTIDE IN RAT MODELS OF ANXIETY", Neuroscience letters, 172(1-2), 1994, pp. 139-142

Abstract

The effects of the acutely administered cholecystokinin (CCK) agonists CCK tetrapeptide (BOC-CCK-4) and sulfated CCK octapeptide (CCK-8S) were examined in four animal models of anxiety in rats. In the elevatedplus maze, BOC-CCK-4 reduced the time spent in the open arms and the number of entries into the open arms. BOC-CCK-4 but not the anorectic acting CCK-8S increased the suppression of feeding in a conflict paradigm based on novelty suppressed feeding in hungry rats. In the two-compartment black-and-white box, BOC-CCK-4 decreased the time spent and locomotor activity in the white compartment. In the ultrasound vocalization test, using rat pups separated from the mother, BOC-CCK-4 increased the number of distress calls. No evidence was found for inducing anxiety-like behaviour by CCK-8S.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:56:48